Clinical trial · Interventional
Memory and MRI Changes With Hippocampus Avoidance Prophylactic Cranial Irradiation(HA-PCI) for Small Cell Lung Cancer(SCLC)
Memory Preservation and Functional Brain Magnetic Resonance Imaging Changes With Conformal Avoidance of the Hippocampal Neural Stem-cell Compartment During Prophylactic Cranial Irradiation for Small Cell Lung Cancer Patients: A Prospective, Randomized Phase-II Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a prospective, randomized phase-II study observing the memory preservation and functional brain MRI changes with conformal avoidance of the hippocampal neural stem-cell compartment during prophylactic cranial irradiation for small cell lung cancer patients.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Small Cell Lung Cancer | Lung Small Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| hippocampus avoidance | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- NO_INTERVENTION
- label
- routine PCI
- description
- PTV:25Gy/10F. Radiation technique: VMAT.
- type
- EXPERIMENTAL
- label
- HA-PCI
- description
- PTV 25Gy/10F. Hippocampus avoidance: decrease the dose to HAZ as the following criteria: Dmin\<9Gy Dmax\<16Gy. Radiation technique: VMAT.
- interventionNames
- Radiation: hippocampus avoidance
Primary outcomes (1)
- measure
- memory preservation
- timeFrame
- 2 years
- description
- responses to Hopkins Verbal Learning Test
Secondary outcomes (3)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: 1. Histologically conformed small cell lung cancer; 2. Complete response (CR)/partial response (PR) after chemo-radiotherapy; 3. ECOG (Eastern Cooperative Oncology Group) : 0-1; 4. No imaging evidence of brain metastasis before PCI; 5. Normal hemodynamic indices before the recruitment (including white blood cell count\>4.0×109/L, neutrophil count\>1.5×109/L, platelet count \>100×109/L, hemoglobin≥90g/l, normal liver/kidney function); 6. Able to understand this study and have signed informed consent. Exclusion Criteria: 1. Unable to receive MRI; 2. Medical history of central nervous system, cognitive or psychological diseases; 3. The expectation of life is less than 6 months; 4. Female in pregnancy or lactating; 5. The researchers consider the patient not appropriate to be enrolled.
References
Publications (0)
Data not yet available