Clinical trial · Interventional
RCT Comparing 19Ga vs 22Ga EBUS-TBNA Needles in Carcinoma.
Randomized Controlled Trial Comparing the Performance of 19 Gauge Versus 22 Gauge EBUS-TBNA Needles in Lung Carcinoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
EBUS-TBNA is often the sole diagnostic test applied in patients with stage IV lung cancer. A limitation of the TBNA needle when using a 22 Gauge needle is the limited ability to procure adequate histological samples. Although a larger 19 Ga needle can procure histological samples as demonstrated by the conventional 19 Ga needle, published data are not existing with respect to molecular diagnostics. A new nitinol-based 19 Ga needle has been developed for EBUS-TBNA. Given the frequent usage of 22 Ga needles for molecular diagnostics and the recent technical advancements in 19 Ga needle technology, we conduct a RCT to compare the performance of both needle types.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Neoplasm | Lung Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| EBUS-TBNA needle | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- 19 Ga EBUS-TBNA needle
- description
- needle aspiration by a flexible 19 Ga needle (Olympus)
- interventionNames
- Device: EBUS-TBNA needle
- type
- ACTIVE_COMPARATOR
- label
- 22 Ga EBUS-TBNA needle
- description
- needle aspiration by a 22 Ga needle (Olympus)
- interventionNames
- Device: EBUS-TBNA needle
Primary outcomes (1)
- measure
- Tissue core
- timeFrame
- 14 months
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * (suspected) stage IV lung carcinoma identified on spiral computed tomography scan * requiring an EBUS-TBNA investigation to obtain intrathoracic hilar or mediastinal lymph node tissue for diagnosis Exclusion Criteria: * uncontrolled coagulopathy * tracheal stenosis
References
Publications (0)
Data not yet available