Clinical trial · Observational
Early Antibiotic Discontinuation in FUO
Early Discontinuation of Empirical Antibacterial Therapy in Febrile Neutropenia: Prospective Observational Study (ANTIBIOSTOP)
NCT02906254CI-TRIAL-00023948ANTIBIOSTOPcompletedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Febrile neutropenia requires prompt initiation of broad-spectrum antibiotics, which can be responsible for side-effects and selection of resistance. This study demonstrates the safety of an early discontinuation of empirical treatments, in carefully selected patients presenting with fever of unknown origin.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Febrile Neutropenia | — | UNRESOLVED | — |
| Hematological Malignancy | Hematopoietic and Lymphoid Cell Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| ECIL-4 guidelines group | Other | — | UNRESOLVED |
| Short-course antibiotic therapy | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- ECIL-4 guidelines group
- description
- For the FUO group, antibiotics were stopped based on two procedures, irrespective of the neutrophil count or expected duration of neutropenia: \- From 1st February 2014 to 30th November 2014, antibiotics were stopped when patients had been afebrile for more than 48 hours, as recommended by the ECIL-4 guidelines
- interventionNames
- Other: ECIL-4 guidelines group
- label
- short-course antibiotic therapy
- description
- For the FUO group, antibiotics were stopped based on two procedures, irrespective of the neutrophil count or expected duration of neutropenia: \- From 1st December 2014 to 30th September 2015, antibiotics were stopped on day 5 in febrile or afebrile patients (short-course antibiotic therapy).
- interventionNames
- Other: ECIL-4 guidelines group
- Other: Short-course antibiotic therapy
Primary outcomes (2)
- measure
- Safety of a short-term antibiotic treatment in afebrile or febrile patients exhibiting FUO, irrespective of their neutrophil count.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * age ≥ 18 years; * presence of a malignant haematological disease combined with chemotherapy-induced neutropenia (polymorphonuclear neutrophil (PMN) count ≤ 500/mm3) * fever defined by tympanic temperature of ≥38°C for ≥1 hour or a single temperature of ≥38.3°C Exclusion Criteria: * Patients without curative care * chronic neutropenia (PMN≤ 500/mm3 for 3 months or more)
References
Publications (0)
Data not yet available
No reference posted for this study.