Clinical trial · Interventional
Study of the Biological Mechanisms Associated With the Immunogenicity in Anaplastic Large Cell Lymphoma ( ALCL ) ALK +
NCT02902874CI-TRIAL-00122265Immuno ALCLcompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To study the correlation between the polymorphism of the main immunity genes and progression-free survival in ALCL of the child.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| ALCL | Anaplastic Large Cell Lymphoma | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Blood sample | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Patients treated for anaplastic large cell lymphoma ( ALCL )
- interventionNames
- Other: Blood sample
Primary outcomes (1)
- measure
- Number of single nucleotide polymorphisms in main immunogenicity genes using VERACODE ILLUMINA technology
- timeFrame
- up to 78 months
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Every patients treated according to COPAD-IGR, HM 89,91 and 97 and ALCL99 protocols and included in related studies * Clinical data registered in SFCE database * Signed consent form Exclusion Criteria: * No ALK expression on tumour * No consent signed
References
Publications (2)
- RESULTPetrazzuolo A, Perez-Lanzon M, Martins I, Liu P, Kepp O, Minard-Colin V, Maiuri MC, Kroemer G. Pharmacological inhibitors of anaplastic lymphoma kinase (ALK) induce immunogenic cell death through on-target effects. Cell Death Dis. 2021 Jul 16;12(8):713. doi: 10.1038/s41419-021-03997-x. PMID 34272360
- DERIVEDAdriana P, Carbonnier V, De Palma FDE, Perez-Lanzon M, Verge V, Quivoron C, Lamant L, Brugieres L, Rigaud C, Ducassou S, Dourthe ME, Le Deley MC, Damm-Welk C, Woessmann W, Minard-Colin V, Maiuri MC, Kroemer G. Association of immune relevant single nucleotide polymorphisms with ALK-positive anaplastic large cell lymphoma presentation and outcome: results of the immuno ALCL study. J Transl Med. 2025 Dec 30;23(1):1434. doi: 10.1186/s12967-025-07410-5. PMID 41469691