Intraoperative Radiation Therapy for Locally Advanced or Recurrent Abdomino-pelvic Solid Tumors With the CivaSheet

Inclusion Criteria:

* Histologic, cytologic, or radiologically evidence of locally advanced, residual or recurrent solid malignancy of the abdomen or pelvis requiring surgical resection
* Maximum projected treatment length 15cm and width 5cm, which are the dimensions of the largest available CivaSheet
* Medically fit and willing to undergo resection of disease
* Age ≥ 18 years
* ECOG performance status 0, 1, or 2
* ANC ≥ 1.5 cells/mm3, PLT≥100,000/mm3, PT/aPTT within normal limits at time of surgery
* Life expectancy, in the clinician's judgment, greater than 1 year.

Exclusion Criteria:

* Women who are pregnant
* Women of childbearing potential who are unwilling or unable to use an acceptable method to avoid pregnancy after the receipt of brachytherapy. Male subjects must also agree to use effective contraception during the treatment period and until 1 year after the completion of brachytherapy
* Patients with any concurrent medical or psychiatric condition or disease which, in the investigator's judgment, would make them inappropriate candidates for entry into this study.
* Patients who, in the investigator's judgment, are unwilling or unable to consent to and return for recommended post-treatment scans as outlined in this study.
* Patients on concurrent anti-cancer therapy, unless specifically agreed to by the patient's medical oncologist and consenting professional.
* Patients with contraindications to general anesthesia, as determined by the treating physician or surgeon