Study of Venetoclax in Combination With Carfilzomib and Dexamethasone in Participants With Relapsed or Refractory Multiple Myeloma (MM)

Inclusion Criteria:

* Eastern Collaborative Oncology Group (ECOG) performance score of less than or equal to 2.
* Documented relapsed or progressive Multiple Myeloma (MM) on or after any regimen or is refractory to the most recent line of therapy.
* Positive for translocation t(11;14) as determined by an analytically validated Fluorescent In Situ Hybridization (FISH) assay per central laboratory testing.
* Received prior treatment with at least 1 prior line of therapy for MM.
* Measurable disease on Screening per International Myeloma Working Group (IMWG) criteria.
* Meets absolute neutrophil count, platelet count, hemoglobin, liver and kidney function laboratory values within 2 weeks prior to first dose of study drug.

Exclusion Criteria:

* Has a pre-existing condition that is contraindicated including.

  * Non-secretory or oligo-secretory MM
  * Active plasma cell leukemia.
  * Waldenström's macroglobulinemia.
  * Primary amyloidosis.
  * POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes).
  * Active hepatitis B or C infection based on screening blood testing.
  * Known active Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
  * Significant cardiovascular disease.
  * Major surgery within 4 weeks prior to first dose.
  * Acute infections requiring antibiotic, antifungal or antiviral therapy within14 days prior to first dose.
  * Peripheral neuropathy ≥ Grade 3 or ≥ Grade 2 with pain within 2 weeks prior to first dose.
  * Uncontrolled diabetes or uncontrolled hypertension within 14 days prior to first dose.
  * Any other medical condition that, in the opinion of the Investigator, would adversely affect the participant's participation in the study.
* History of other active malignancies, including myelodysplastic syndrome (MDS), within the past 3 years prior to study entry Other protocol defined inclusion/exclusion criteria could apply