Clinical trial · Interventional
Underwater Resection of Non-pedunculated Colorectal Lesions
Underwater Resection of Non-pedunculated Colorectal Lesions: A Randomized Controlled Trial
NCT02889679CI-TRIAL-00036227completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of this study is to compare the efficacy of underwater resection (polypectomy) versus conventional polypectomy techniques for small and large colorectal lesions identified during colonoscopy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Neoplasms | Colorectal Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Conventional (gas distended colon) resection | Procedure | — | UNRESOLVED |
| Standard polypectomy | Procedure | — | UNRESOLVED |
| Underwater resection | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Underwater resection
- description
- All eligible lesion identified in a patient will be resected by the underwater technique. Excluded lesions will be resected by standard polypectomy.
- interventionNames
- Procedure: Underwater resection
- Procedure: Standard polypectomy
- type
- ACTIVE_COMPARATOR
- label
- Conventional resection
- description
- All eligible lesion identified in a patient will be resected by the conventional (gas distended colon) resection techniques. Excluded lesions will be resected by standard polypectomy.
- interventionNames
- Procedure: Conventional (gas distended colon) resection
- Procedure: Standard polypectomy
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adult (≥18 years old) male and female patients. * Scheduled for outpatient colonoscopy. * Patient able to provide informed consent. * Benign, small (6-9mm) and large (≥1cm) non-pedunculated colorectal lesions. Exclusion Criteria: * Diminutive (≤5mm) and pedunculated polyps. * Lesions suspected of harboring deep submucosal invasion. * Patients who decline to participate or are unable to provide informed consent.
References
Publications (3)
- BACKGROUNDPohl H, Srivastava A, Bensen SP, Anderson P, Rothstein RI, Gordon SR, Levy LC, Toor A, Mackenzie TA, Rosch T, Robertson DJ. Incomplete polyp resection during colonoscopy-results of the complete adenoma resection (CARE) study. Gastroenterology. 2013 Jan;144(1):74-80.e1. doi: 10.1053/j.gastro.2012.09.043. Epub 2012 Sep 25. PMID 23022496
- BACKGROUNDBinmoeller KF, Weilert F, Shah J, Bhat Y, Kane S. "Underwater" EMR without submucosal injection for large sessile colorectal polyps (with video). Gastrointest Endosc. 2012 May;75(5):1086-91. doi: 10.1016/j.gie.2011.12.022. Epub 2012 Feb 25. PMID 22365184
- DERIVEDYen AW, Leung JW, Wilson MD, Leung FW. Underwater versus conventional endoscopic resection of nondiminutive nonpedunculated colorectal lesions: a prospective randomized controlled trial (with video). Gastrointest Endosc. 2020 Mar;91(3):643-654.e2. doi: 10.1016/j.gie.2019.09.039. Epub 2019 Oct 16. PMID 31628954