Clinical trial · Observational
Elderly CAncer Patient
Elderly Cancer Patient: ELCAPA Cohort Survey
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The management of older patients with cancer has become a major public health concern in Western countries because of the aging of the population and steady increase in cancer incidence with advancing age. Cancer treatment of aged patients is complex due to comorbidities, polypharmacy and functional status. The heterogeneity of the older population in terms of comorbidities and functional status may explain the difficulty in establishing management recommendations. Study hypothesis is that a geriatric consultation using Geriatric Assessment (GA) can evaluate patient's resource and strengths, in order to help oncologist to define the most effective treatment. The GA developed by geriatricians and recommended by the International Society of Geriatric Oncology (SIOG), is a multidimensional assessment of general health status; comorbidities; functional status; nutritional, cognitive, psychological, and social parameters; and medications. The GA uses validated geriatric scales to produce an inventory of problems, which can then serve to develop an individualized geriatric intervention plan; it may be an important step in selecting elderly patients for cancer screening and treatment. The objectives are: * To assess the role of GA for decision making process for older patients with cancer * To identify geriatric and oncologic factors associated with overall survival, treatment feasibility, toxicities, morbidities * To develop and/or validate screening tests for frailty in geriatric oncology * To develop and validate frailty classifications Method: The ELCAPA (ELderly CAncer PAtient) survey is a French multicentric prospective study that includes all patients age 70 years or older who has a diagnosis of solid cancer or hematologic malignancies in French hospitals
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hematologic Malignancies | Hematopoietic and Lymphoid Cell Neoplasm | PROBABILISTIC | 0.70 |
| Solid Cancer | Malignant Solid Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Extensive GA | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Elderly cancer patient cohort
- description
- Patients aged 70 years or older, who had diagnosis of cancer in participating sites (including hematologic malignancies), and referred to a geriatrician for geriatric assessment (GA)
- interventionNames
- Other: Extensive GA
Primary outcomes (1)
- measure
- Difference between initial oncologist treatment proposal and final treatment selected after geriatric assessment
- timeFrame
- through multidisciplinary meeting decision, an average of 2 weeks after GA (+/-1 week).
Secondary outcomes (3)
- measure
- Chemotherapy toxicities using Common Terminology Criteria for Adverse Events
- timeFrame
- through chemotherapy treatment completion, an average of 6-months after inclusion (+/- 3 months) (according to curative or palliative and chemotherapy protocols).
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * Patient aged 70 years or older * Diagnosed cancer at all stage * Referred to a geriatrician for GA * Given oral non-opposition from patient or a legally mandated person Exclusion Criteria: * Oral opposition
References
Publications (4)
- DERIVEDde Salins V, Martinez-Tapia C, Gay P, Morel A, Bringuier M, Boudou-Rouquette P, Corsin L, Aregui A, Canovas J, Rautou PE, Soubeyran P, Bellera C, Canoui-Poitrine F, Paillaud E, Poisson J. The Fibrosis-4 score is associated with overall mortality and severe haematological toxicity in older patients with cancer: Analysis of two prospective cohort studies. Int J Cancer. 2025 Dec 15;157(12):2506-2520. doi: 10.1002/ijc.70071. Epub 2025 Aug 6. PMID 40767026
- DERIVEDFrasca M, Martinez-Tapia C, Jean C, Chanteclair A, Galvin A, Bergua V, Hagege M, Caillet P, Laurent M, Brain E, Mathoulin-Pelissier S, Paillaud E, Canoui-Poitrine F. Serious Health-Related Suffering Impairs Treatments and Survival in Older Patients With Cancer. J Pain Symptom Manage. 2024 Nov;68(5):506-515.e5. doi: 10.1016/j.jpainsymman.2024.08.002. Epub 2024 Aug 13. PMID 39142494
- DERIVEDGonzalez Serrano A, Laurent M, Barnay T, Martinez-Tapia C, Audureau E, Boudou-Rouquette P, Aparicio T, Rollot-Trad F, Soubeyran P, Bellera C, Caillet P, Paillaud E, Canoui-Poitrine F. A Two-Step Frailty Assessment Strategy in Older Patients With Solid Tumors: A Decision Curve Analysis. J Clin Oncol. 2023 Feb 1;41(4):826-834. doi: 10.1200/JCO.22.01118. Epub 2022 Oct 28. PMID 36306481
- DERIVEDMartinez-Tapia C, Diot T, Oubaya N, Paillaud E, Poisson J, Gisselbrecht M, Morisset L, Caillet P, Baudin A, Pamoukdjian F, Broussier A, Bastuji-Garin S, Laurent M, Canoui-Poitrine F. The obesity paradox for mid- and long-term mortality in older cancer patients: a prospective multicenter cohort study. Am J Clin Nutr. 2021 Jan;113(1):129-141. doi: 10.1093/ajcn/nqaa238. Epub 2020 Sep 5. PMID 32889525