Clinical trial · Interventional
Metformin in Breast Cancer, Visualized With Positron Emission Tomography
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The general purpose of the trial is to investigate whether metformin is taken up into the breast tumor. Studies in the last few years have shown an effect of metformin on cell proliferation on breast cancer. It is though unclear whether the effect on tumor is direct, indirect or a combination of the two. The investigators plan to: * investigate if metformin is taken up in breast cancer using our novel 11C-metformin tracer and positron emission tomography (PET) * investigate whether the uptake is correlated to the amounts of organic cation transporters (OCT1-3, MATE 1 \&2 and PMAT) using quantitive polymerase chain reaction (qPCR).
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 11C-metformin | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- 11C-metformin
- description
- All participants allocated to the study will be included in this arm
- interventionNames
- Radiation: 11C-metformin
Primary outcomes (1)
- measure
- Metformin uptake in breast cancer
- timeFrame
- 12 months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 50 Years
Show eligibility criteria text
Inclusion Criteria: * over 50 years * C. mammae * Tumor size: \> 10 mm in diameter * Unilateral cancer * WHO performance status 0-1 Exclusion Criteria: * Severe heart- or kidney failure * Pregnant or breast feeding * If the patient is found not eligible for participation in the study på principal investigator
References
Publications (0)
Data not yet available