Clinical trial · Interventional
Neoadjuvant Chemotherapy for the Treatment of Resectable Locally Advanced Colon Cancer
A Randomized Controlled Clinical Trial to Investigate the Effect of Neoadjuvant Chemotherapy for the Treatment of Resectable Locally Advanced Colon Cancer
NCT02882269CI-TRIAL-00023706unknownPhase 2 / Phase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
A randomized controlled clinical trial to compare the short and long outcomes of Neoadjuvant chemotherapy with postoperative chemotherapy in patients with resectable locally advanced colon cancer
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colon Cancer | Malignant Colon Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Neoadjuvant chemotherapy | Drug | — | UNRESOLVED |
| Postoperative chemotherapy | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Postoperative chemotherapy
- description
- Patients receive 6 months of chemotherapy after surgery.
- interventionNames
- Drug: Postoperative chemotherapy
- type
- EXPERIMENTAL
- label
- Neoadjuvant chemotherapy
- description
- Patients receive 3-4 cycles of chemotherapy before surgery. Preoperative and postoperative chemotherapy will be given for a total of 6 months.
- interventionNames
- Drug: Neoadjuvant chemotherapy
Primary outcomes (1)
- measure
- disease-free survival
- timeFrame
- 3 years
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Patients suitable for curative surgery between 18 to 80 years old; * American Society of Anesthesiologists(ASA) grade I-III; * Pathological diagnosis of adenocarcinoma; * Tumor located between the cecum and sigmoid colon; * Enhanced CT scan of chest, abdominal and pelvic cavity: preoperative assessment of tumor stage is T3-T4 N0 or T any N+ (according to the National Comprehensive Cancer Network(NCCN) clinical practice guidelines in oncology: colon cancer version 2.2015);there is no distant metastasis; * Informed consent; * No preoperative chemoradiotherapy; * No history of familial adenomatous polyposis, ulcerative colitis or Crohn's disease. Exclusion Criteria: * Pregnant patient; * History of psychiatric disease; * Use of systemic steroids; * Simultaneous multiple primary colorectal cancer; * Preoperative imaging examination results show: 1. distant metastasis; 2. unable to perform R0 resection; * Postoperative pathology of T1-T2 N0; * History of any other malignant tumor in recent 5 years; * Patients need emergency operation: mechanic ileus, perforation.
References
Publications (0)
Data not yet available
No reference posted for this study.