Clinical trial · Interventional
Effect of Water Exchange Method on Adenoma Miss Rates in Patients Undergoing Selective Polypectomy
Effect of Water Exchange Method on Adenoma Miss Rates in Patients Undergoing Selective Polypectomy: a Single-centered, Randomized Controlled Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Patients with colorectal adenomas are suggested to receive polypectomy. A substantial number of adenomas may be missed in patients with polyps found by previous colonoscopy. And water exchange (WE) method may increase the detection of missed adenoma compared with traditional air insufflation (AI) colonoscopy. The investigators aim to investigate whether water exchange colonoscopy method, compared with air insufflation method, can improve the detection of missed adenomas in patients undergoing selective polypectomy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Adenoma | Adenoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Air insufflation (AI) method. | Other | — | UNRESOLVED |
| Water exchange (WE) method | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Water exchange (WE) method
- description
- Water exchange (WE) method was used for insertion to the cecum.
- interventionNames
- Other: Water exchange (WE) method
- type
- ACTIVE_COMPARATOR
- label
- Air insufflation (AI) method
- description
- Air insufflation (AI) method was used for insertion to the cecum.
- interventionNames
- Other: Air insufflation (AI) method.
Primary outcomes (1)
- measure
- Adenoma miss rate
- timeFrame
- 12 months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Age 18-80 patients undergoing selective polypectomy Exclusion Criteria: * Polyps found more than 6 months * Patients with polyposis syndrome or hereditary nonpolyposis colorectal cancer * Patients with history of inflammatory bowel disease * Patients with planning to undergo Endoscopic Submucosal Dissection(ESD) * Patients not undergoing standard bowel preparation * Patients with solid feces in the last stool after bowel preparation * Patients considered to be high risk for bleeding during Endoscopic mucosal resection (EMR), e.g. using antiplatelet drugs (clopidogrel) within 5 days before the current colonoscopy * Hemodynamically unstable * Pregnant women * Unable to provide informed consent
References
Publications (3)
- BACKGROUNDVeitch AM, Vanbiervliet G, Gershlick AH, Boustiere C, Baglin TP, Smith LA, Radaelli F, Knight E, Gralnek IM, Hassan C, Dumonceau JM. Endoscopy in patients on antiplatelet or anticoagulant therapy, including direct oral anticoagulants: British Society of Gastroenterology (BSG) and European Society of Gastrointestinal Endoscopy (ESGE) guidelines. Gut. 2016 Mar;65(3):374-89. doi: 10.1136/gutjnl-2015-311110. PMID 26873868
- BACKGROUNDHewett DG, Rex DK. Cap-fitted colonoscopy: a randomized, tandem colonoscopy study of adenoma miss rates. Gastrointest Endosc. 2010 Oct;72(4):775-81. doi: 10.1016/j.gie.2010.04.030. Epub 2010 Jun 25. PMID 20579648
- DERIVEDRen G, Wang X, Luo H, Yao S, Liang S, Zhang L, Dong T, Chen L, Tao Q, Guo X, Han Y, Pan Y. Effect of water exchange method on adenoma miss rate of patients undergoing selective polypectomy: A randomized controlled trial. Dig Liver Dis. 2021 May;53(5):625-630. doi: 10.1016/j.dld.2020.11.012. Epub 2020 Dec 31. PMID 33390353