Clinical trial · Observational
Hepatocellular Carcinoma and Rheumatoid Arthritis
NCT02880306CI-TRIAL-00023660completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Rheumatoid arthritis(RA) is a disorder with altered immunologic function and increased risk of developing malignancies, while studies examining the association between hepatocellular carcinoma (HCC) and RA remain lacking. The investigators aimed to investigate the risk of HCC between participants with and without RA.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Carcinoma, Hepatocellular | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| RA | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- RA cohort
- description
- RA was diagnosed based on the 1987 American College of Rheumatology diagnostic criteria.
- interventionNames
- Other: RA
- label
- Non-RA cohort
- description
- Participants who were ≥18 years of age, without a RA diagnosis
Primary outcomes (1)
- measure
- the risk of developing hepatocellular carcinoma
- timeFrame
- between Jan 1, 1999 and Dec 31, 2009
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 99 Years
Show eligibility criteria text
Inclusion Criteria: * subjects were required to have ≥2 RA diagnosis (International Classification of Diseases, Ninth Revision \[ICD-9-CM\]-codes 714.0x), and to be ≥18 years of age on the date of first diagnosis. And inclusion in the Registry for Catastrophic Illness Patient Database (RCIPD) Exclusion Criteria: * who were diagnosed with RA only once during the study interval, \<18 years of age when first diagnosed with RA, first diagnosed with RA after July 1, 2009, or not registered in the RCIPD were excluded
References
Publications (1)
- DERIVEDHsu CS, Lang HC, Huang KY, Chao YC, Chen CL. Risks of hepatocellular carcinoma and cirrhosis-associated complications in patients with rheumatoid arthritis: a 10-year population-based cohort study in Taiwan. Hepatol Int. 2018 Nov;12(6):531-543. doi: 10.1007/s12072-018-9905-7. Epub 2018 Nov 14. PMID 30426396