Clinical trial · Observational
Molecular Determinants of Response to Preoperative Therapy in Patients With Locally Advanced Colorectal Cancer
NCT02877056CI-TRIAL-00038820unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this laboratory research is to look for genes that can predict which patients will achieve a complete disappearance of their colorectal cancer after treatment like chemotherapy, radiation, or other therapy. This is an investigational study. Up to 350 patients will take part in this study. All will be enrolled at MD Anderson.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Endoscopy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Colorectal Cancer
- description
- Participants undergo standard endoscopy before therapy. Tissue samples taken from the tumor and normal colorectal tissue.
- interventionNames
- Procedure: Endoscopy
Primary outcomes (1)
- measure
- Predictive Tumor Cell Biomarkers After Chemoradiation Treatment for Colorectal Cancer
- timeFrame
- 1 day
- description
- Tissue taken at endoscopy undergoes testing for tumor cell biomarkers to identify patients who achieve complete response (CR).
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patients with colorectal adenocarcinoma (diagnosis based on either MDACC or outside records) 2. Patients scheduled to undergo neoadjuvant therapy per MDACC care team. 3. Patients over 18 years of age. 4. Patients with distant organ findings deemed to be indeterminate or metastatic will be enrolled at the surgeon's discretion. 5. Patients who have been deemed medically safe to undergo endoscopic biopsy by the physician performing the procedure. 6. Patients who would have typically undergone preoperative therapy followed by surgery but for specific reasons at the discretion of the treating physician underwent surgery without preoperative therapy may be enrolled at the surgeons' discretion. Exclusion Criteria: N/A
References
Publications (0)
Data not yet available
No reference posted for this study.