Clinical trial · Interventional
Endoresection of the Tumor Scar or Transpupillary Thermotherapy for the Treatment of Large Uveal Melanomas (Endoresection-Laser)
Phase II Evaluating Endoresection of the Tumor Scar or Transpupillary Thermotherapy When Endoresection is Not Feasible After Proton Beam Therapy for the Treatment of Large Uveal Melanomas
NCT02874040CI-TRIAL-00093354completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Study the efficacy of endoresection of the tumor scar or, when surgery is not possible, transpupillary thermotherapy on the tumor scar to prevent neovascular glaucoma and secondary enucleation
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Melanoma, Uveal | Uveal Melanoma | ONTOLOGY_EXACT | 0.98 |
| Uveal Melanoma | Uveal Melanoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Endoresection | Procedure | — | UNRESOLVED |
| Laser diode | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Experimental
- description
- endoresection of the tumor scar or, when surgery is not possible, transpupillary thermotherapy on the tumor scar
- interventionNames
- Procedure: Endoresection
- Procedure: Laser diode
Primary outcomes (1)
- measure
- Post-treatment complication incidence.
- timeFrame
- 3 years
- description
- observed complications are : Number of glaucomas, numbrer of retinal detachment and number of secondary enucleations.
Secondary outcomes (2)
- measure
- Measure of tumor scar thickness
- timeFrame
- 3 years
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Tumor of 7 mm of thickness or more * Patients treated by proton beam therapy * Patients aged at least 18 years * Patients clearly informed of the study, having received the letter of information and signed the consent Exclusion Criteria: * Massive extrascleral extension posterior to the equator * Patients with metastasis at diagnosis. * Patients with glaucoma before the radiation therapy * Patients with opaque media preventing transpupillary thermotherapy * Patients for whom follow up will be difficult due to geographical, social or psychological reasons
References
Publications (0)
Data not yet available
No reference posted for this study.