Tepotinib Phase II in NSCLC Harboring MET Alterations (VISION)

Inclusion Criteria:

* Signed, written informed consent by participant or legal representative prior to any trial-specific screening procedure
* Male or female, greater than or equal to (\>=) 18 years of age (or have reached the age of majority according to local laws and regulations)
* Measurable disease confirmed by an independent review committee (IRC) in accordance with RECIST version 1.1
* Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0 or 1
* A female participant was eligible to participate if she is not pregnant, not breastfeeding, and at least one of the following conditions applies:
* Not a woman of childbearing potential OR
* A woman of childbearing potential who agrees to use a highly effective contraception
* A male participant must agree to use and to have their female partners of childbearing potential to use a highly effective contraception
* Histologically or cytologically confirmed advanced (locally advanced or metastatic) NSCLC (all types including squamous and sarcomatoid)
* Treatment naïve participant in first-line or pretreated participant with no more than 2 lines of prior therapy
* Participants with MET alterations, namely METex14 skipping alterations in plasma and/or tissue as determined by the central laboratory or by an assay with appropriate regulatory status

Exclusion Criteria:

* Participants with characterized Epidermal Growth Factor Receptor (EGFR) activating mutations that predict sensitivity to anti-EGFR-therapy
* Participants with characterized Anaplastic Lymphoma Kinase (ALK) rearrangements that predict sensitivity to anti-ALK therapy
* Participants with symptomatic brain metastases who are neurologically unstable
* Any unresolved toxicity Grade 2 or more according to National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) from previous anticancer therapy
* Need for transfusion within 14 days prior to the first dose of trial treatment
* Prior chemotherapy, biological therapy, radiation therapy, hormonal therapy for anti-cancer purposes, targeted therapy, or other investigational anticancer therapy (not including palliative radiotherapy at focal sites) within 21 days prior to the first dose of trial treatment;
* Participants who have brain metastasis as the only measurable lesion
* Inadequate hematological, liver, renal, cardiac function
* Prior treatment with other agents targeting the Hepatocyte Growth Factor c(HGF/c) -Met pathway
* Hypertension uncontrolled by standard therapies (not stabilized to \< 150/90 mmHg)
* Past or current history of neoplasm other than Non-small Cell Lung Cancer (NSCLC), except for curatively treated non-melanoma skin cancer, in situ carcinoma of the cervix, or other cancer curatively treated and with no evidence of disease for at least 5 years
* Medical history of difficulty swallowing, malabsorption, or other chronic gastrointestinal disease, or conditions that may hamper compliance and/or absorption of the test product
* Major surgery within 28 days prior to Day 1 of trial treatment
* Known infection with human immunodeficiency virus, or an active infection with hepatitis B or hepatitis C virus
* Substance abuse, active infection, or other acute or chronic medical or psychiatric condition or laboratory abnormalities that might increase the risk associated with trial participation at the discretion of Investigators
* Known hypersensitivity to any of the trial treatment ingredients
* Legal incapacity or limited legal capacity
* Any other reason that, in the opinion of the Principal Investigator, precludes the participant from participating in the trial
* Participation in another clinical trial within the past 30 days