A Study of Hutchison MediPharma Limited(HMPL)-523 in Patients With Relapsed or Refractory Mature B-cell Neoplasms

Inclusion Criteria:

1. Signed Informed Consent Form
2. Age \>=18 years
3. Histologically relapsed or refractory mature B-cell Neoplasms, have failed at least one prior therapy or patients who are unable to tolerate standard therapy or no curative therapy or therapy of higher priority exists
4. Eastern Cooperative Oncology Group（ECOG） performance status of 0 or 1
5. Expected survival of more than 24 weeks as determined by the investigator
6. In expansion stage, Subjects should have at least one dual diameter measurable lesion expect for subject with CLL or subject with LPL/WM with abonormal immunoglobulin

Exclusion Criteria:

1. Patients with primary central nervous system(CNS) lymphoma
2. Any of the following laboratory abnormalities:

   * Absolute neutrophil count\<1.5×109/L
   * Hemoglobin \<80g/L
   * Platelet\<75 ×109 /L
3. Inadequate organ function, defined by the following:

   * Total bilirubin \>1.5the ULN with the following exception:

     * Patients with known Gilbert disease who have serum bilirubin level ≤3 the upper limit of normal(ULN) and normal Aspartate aminotransferase(AST)/Alanine aminotransferase(ALT) may be enrolled.
4. AST and/or ALT \> 2.5 the ULN with the following exception:Patients with documented disease infiltration of the liver may have AST and/or ALT levels ≤ 5 the ULN.
5. Serum amylase or lipase \> the ULN
6. Serum creatinine \> 1.5 the ULN or estimated creatinine clearance \< 50 mL/min
7. International normalized ratio (INR)\>1.5 the ULN or activated partial thromboplastin time (aPTT)\>1.5 the ULN
8. Clinically significant history of liver disease, including cirrhosis, current alcohol abuse, or current known active infection with HIV, hepatitis B virus (HBV), or hepatitis C virus (HCV)
9. Pregnant (positive pregnancy test) or lactating women
10. New York Heart Association (NYHA) Class II or greater congestive heart failure
11. Congenital long QT syndrome or corrected QT interval (QTc) \> 480 msec
12. Currently use medication known to cause QT prolongation.
13. Subjects with presence of clinically detectable second primary malignant tumors at enrollment, or other malignant tumors within the last 2 years (with the exception of radically treated basal cell or squamous cell carcinoma of the skin, in situ cervix, or in situ breast cancer).
14. Any anti-cancer therapy, including chemotherapy, hormonal therapy, biologic therapy, or radiotherapy within 3 weeks prior to initiation of study treatment
15. Herbal therapy ≤1 week prior to initiation of study treatment
16. Prior treatment with any spleen tyrosine kinase (SYK) inhibitors (Fostamatinib)
17. Prior allogeneic stem cell transplant within 6 months prior to initiation of study treatment or with any evidence of active graft versus host disease or requirement for immunosuppressants within 28 days prior to initiation of study treatment
18. Clinically significant active infection (pneumonia)
19. Major surgical procedure within 4 weeks prior to initiation of study treatment
20. History of myocardial infarction or unstable angina within 6 months prior to initiation of study treatment
21. Inability to take oral medication, prior surgical procedures affecting absorption, or active peptic ulcer disease
22. Adverse events from prior anti-cancer therapy that have not resolved to Grade ≤1, except for alopecia