Clinical trial · Interventional
Comparison of Biannual Ultrasonography and Annual Unenhanced Magnetic Resonance Imaging for HCC Surveillance
Comparison of Biannual Ultrasonography and Annual Unenhanced Magnetic Resonance Imaging as a Surveillance Test for HCC in Patients With Liver Cirrhosis
NCT02854241CI-TRIAL-00050698unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to investigate clinical feasibility of annual non-contrast magnetic resonance imaging for surveillance of hepatocellular carcinoma in high-risk group, in comparison with biannual ultrasonography.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cirrhosis | — | UNRESOLVED | — |
| Hepatocellular Carcinoma | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Annual noncontrast liver MRI | Procedure | — | UNRESOLVED |
| Biannual ultrasonography | Procedure | — | UNRESOLVED |
| Contrast enhanced liver CT | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- LC group
- description
- LC group under surveillance of biannual ultrasonography and annual noncontrast liver MRI. Six month after the last MRI, contrast enhanced liver CT is performed to investigate presence of HCC.
- interventionNames
- Procedure: Biannual ultrasonography
- Procedure: Annual noncontrast liver MRI
- Procedure: Contrast enhanced liver CT
Primary outcomes (1)
- measure
- sensitivity for detecting HCC
- timeFrame
- 6 months after last patient's MRI
Secondary outcomes (1)
- measure
- specificity for detecting HCC
- timeFrame
- 6 months after last patient's MRI
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 40 Years
Show eligibility criteria text
Inclusion Criteria: * equal to or older than 40 years * under surveillance using biannual ultrasonography (USG) and presence of liver USG within 6 months (+/- 1month) * risk index is equal to or higher than 2.33 (Risk Index = 1.65 (if the prothrombin activity is \<=75%) + 1.41 (if the age is 50 years or older) + 0.92 (if the platelet count is \<=100x10(3)/mm3) + 0.74 (if the presence of HCV or HBsAg is positive)). * signed informed consent Exclusion Criteria: * under 40 years * history of HCC * patients with pregnancy or nursing * any contraindication of MRI * any contraindication of CT
References
Publications (0)
Data not yet available
No reference posted for this study.