Therapeutic Resistance Prediction of Tyrosine Kinase Inhibitors

The investigators propose a non-invasive prognostic tool for TKIs resistance in patients with stage IV EGFR-mutant non-small cell lung cancer (NSCLC) by computed tomography phenotypic features, which can be conveniently translated to facilitate the pre-therapy individualized management of EGFR TKIs in this disease.

Sex

All

Minimum age

20 Years

Inclusion Criteria:

* Eligible patients were diagnosed with NSCLC, and stage IV according to the TNM system classification of the American Joint Committee on Cancer.
* Presence of activating EGFR mutations.
* Age 20 years or older, and no history of systemic anticancer therapy for advanced disease.
* Patients who underwent first-line or second-line EGFR TKIs were eligible for inclusion.
* All patients had to be capable of undergoing contrast-enhanced CT, and pretreatment CT was strictly controlled in two weeks before the EGFR TKIs starts.

Exclusion Criteria:

* Based on the criteria above, patients who underwent resection for local advanced or metastatic disease were withdrawn from the study.

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