Clinical trial · Observational
Cost and Medical Care of Patients With Advanced Serious Illness in Singapore (COMPASS) Study
NCT02850640CI-TRIAL-00070535COMPASSunknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Cost and Medical Care of Patients with Advanced Serious Illness in Singapore (COMPASS),is a cohort study which aims to capture health care utilization, cost, and quality of life indicators of patients with advanced cancer and their primary caregivers.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (6)
- measure
- Change in overall quality of life among patients through the last year of life.
- timeFrame
- From recruitment to death of patient (baseline, 3 month, 6 months, 9 months, 12 months)
- description
- We will assess patient's quality of life through FACT-G
- measure
- Change in anxiety and depression among patients through the last year of life
- timeFrame
- From recruitment to death of patient (baseline, 3 month, 6 months, 9 months, 12 months)
- description
- We will assess patients' anxiety and depression through the Hospital Anxiety and Depression Scale (HADS).
- measure
- Change in pain severity among patients through the last year of life
- timeFrame
- From recruitment to death of patient (baseline, 3 month, 6 months, 9 months, 12 months)
- description
- We will assess pain reported by patients through visual analog pain scores
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 21 Years
Show eligibility criteria text
Inclusion Criteria for patients are: 1. Age ≥ 21 years old 2. Singaporean or Singapore Permanent Resident 3. Diagnosis of advanced/ stage IV solid cancer (for non-breast and non-prostate cancer patients). If it is breast or prostate cancer it should be stage IV with metastases to an organ site. 4. Graded 0-2 on the Eastern Cooperative Oncology Group Performance Status 5. Intact cognition (of patients ≥60 years of age) as determined by the Abbreviated Mental Test. If patient fails the cognitive test, he/she continues to be eligible for the study although self-reported data will no longer be collected. The Legal Representative of the patient will be approached for providing consent on behalf of the patient, to allow access to review of patient's medical and billing records The exclusion criteria for patients are 1. Patients who are not Singaporeans or Singapore Permanent Residents 2. Patients who are graded 3 (confined to bed more than 50% of waking hours) and 4 (completely disabled) on the Eastern Cooperative Oncology Group Performance Status. 3. Patients who are ≤21 years of age The inclusion criteria for primary informal caregivers are: 1. Age ≥ 21 years old 2. Main person or one of the main providing care to the patient (e.g. accompanying patient for doctor's visits, helping the patient with day to day activities) 3. Main person or one of the main ensuring provision of care (e.g. supervision of foreign domestic worker so that the patient is looked after) 4. Main person or one of the main involved in making decisions regarding treatment the patient receives 5. Patient they are caring for is enrolled in the study The exclusion criteria for primary informal caregivers are: a) Foreign domestic workers/ maids will be excluded from this study The inclusion criteria for physicians are: 1. Age ≥ 21 years old 2. Patients they are treating are enrolled in the study
References
Publications (4)
- DERIVEDLee J, Shafiq M, Malhotra R, Ozdemir S, Teo I, Malhotra C. Trajectories of Health-related quality of life in patients with Advanced Cancer during the Last Year of Life: findings from the COMPASS study. BMC Palliat Care. 2022 Oct 14;21(1):183. doi: 10.1186/s12904-022-01075-3. PMID 36242033
- DERIVEDOzdemir S, Ng S, Chaudhry I, Teo I, Malhotra C, Finkelstein EA; COMPASS Study Group. Caregiver-Reported Roles in Treatment Decision Making in Advanced Cancer and Associated Caregiving Burden and Psychological Distress: A Longitudinal Study. Med Decis Making. 2023 Feb;43(2):191-202. doi: 10.1177/0272989X221125408. Epub 2022 Sep 16. PMID 36113405
- DERIVEDMalhotra C, Bundoc F, Chaudhry I, Teo I, Ozdemir S, Finkelstein E; COMPASS study group. A prospective cohort study assessing aggressive interventions at the end-of-life among patients with solid metastatic cancer. BMC Palliat Care. 2022 May 16;21(1):73. doi: 10.1186/s12904-022-00970-z. PMID 35578270
- DERIVEDTeo I, Singh R, Malhotra C, Ozdemir S, Dent RA, Kumarakulasinghe NB, Yeo WL, Cheung YB, Malhotra R, Kanesvaran R, Yee ACP, Chan N, Wu HY, Chin SM, Allyn HYM, Yang GM, Neo PSH, Nadkarni NV, Harding R, Finkelstein EA. Cost of Medical Care of Patients with Advanced Serious Illness in Singapore (COMPASS): prospective cohort study protocol. BMC Cancer. 2018 Apr 23;18(1):459. doi: 10.1186/s12885-018-4356-z. PMID 29688843