Screening of Tobacco-induced Cancers by Low-dose CT-scanner and Identification of Circulating Tumor Cells

Inclusion Criteria:

* Subject with at least a cumulative smoking 30 pack-years,
* Active or weaned smoking since less than 15 years,
* Who consults or is hospitalized in a medical services or vascular surgery 'Paris Saint Joseph Hospital Group' (GHPSJ) or 'the European Hospital Georges Pompidou' (HEGP) for occlusive arterial disease or aneurysm the abdominal aorta,
* Accepting the repeat CT scans and blood tests, as provided for by the protocol and additional investigations which might be necessitated by the detection of abnormality (s) to previous reviews,
* Accepting, in case of continuing active smoking, engage in smoking cessation process.

Exclusion Criteria:

* Bronchial history of cancer,
* Diagnosis and / or previous treatment of another cancer within 5 years prior to study entry, with the exception of skin tumors and non melanomatous carcinoma in situ,
* Anterior resection pulmonary parenchyma, severe respiratory failure against-indicating any invasive procedure on the lung,
* Signs of presence and / or symptoms that may be due to a pre-existing cancer (eg, unexplained weight loss of more than 10% of initial body weight over the last 12 months, hemoptysis, ...)
* ECOG activity index ≥ 2,
* Acute respiratory infection that led to antibiotic therapy within 12 weeks prior to study entry,
* Renal impairment does not authorize, where appropriate, a contrast agent injection,
* Comorbidity (s) may increase the risk of death during the course of the trial.