Clinical trial · Observational
Evaluation of Corrected Carotid Artery Flow Time as a Predictor of Fluid Responsiveness in Spontaneous Breathing Patients
NCT02843477CI-TRIAL-00033812completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
It is still challenging to assess intravascular volume status in spontaneously breathing patients. Recently, the measurement of corrected flow time in carotid artery was introduced as quite useful, simple and noninvasive for the evaluation of circulating blood volume change. The aim of this study is to evaluate whether corrected carotid artery flow time as determined by ultrasonography can be a predictor of fluid responsiveness in spontaneously breathing patients before induction of general anesthesia.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Tumor | Brain Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| ultrasonographic measurement of corrected flow time in carotid artery | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Fluid loading group
- description
- Spontaneously breathing patients before induction of general anesthesia who receive fluid loading
- interventionNames
- Device: ultrasonographic measurement of corrected flow time in carotid artery
Primary outcomes (2)
- measure
- ultrasonographic measurement of corrected flow time in carotid artery
- timeFrame
- right before fluid loading
- description
- The ultrasonographic measurement of corrected flow time in carotid artery will be performed before fluid loading.
- measure
- ultrasonographic measurement of corrected flow time in carotid artery
- timeFrame
- 5 minutes after fluid loading
- description
- The ultrasonographic measurement of corrected flow time in carotid artery will be performed 5 minutes after fluid loading.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 19 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * adult patients (19-80 years of age) who were scheduled to undergo elective neurosurgery for brain tumor Exclusion Criteria: * BMI \> 35 or \< 15 kg/m2 * the presence of carotid artery stenosis \> 50% * systolic blood pressure \> 160 mmHg * cardiac rhythm other than sinus * intracardiac shunt 6. valvular heart disease * a left ventricular ejection fraction of \< 50% * right ventricular dysfunction 9 * chronic obstructive pulmonary disease * pulmonary hypertension * chronic kidney disease (eGFR \< 60 mL/min/1.73m2) * pregnancy
References
Publications (1)
- DERIVEDKim DH, Shin S, Kim N, Choi T, Choi SH, Choi YS. Carotid ultrasound measurements for assessing fluid responsiveness in spontaneously breathing patients: corrected flow time and respirophasic variation in blood flow peak velocity. Br J Anaesth. 2018 Sep;121(3):541-549. doi: 10.1016/j.bja.2017.12.047. Epub 2018 Apr 12. PMID 30115251