Clinical trial · Interventional
Exercise Preconditioning and Breast Cancer Cardiotoxicity
Aerobic Interval Exercise Preconditioning to Prevent Cardiometabolic and Neuropsychological Complications of Anthracycline Based Breast Cancer Chemotherapy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to determine whether a supervised exercise-training program, initiated prior to chemotherapy induction (pre-conditioning) and continued throughout chemotherapy treatment, can preserve short- and long-term cardiovascular performance, skeletal muscle function, cognitive ability and quality of life better than current standard or care recommendations for exercise during chemotherapy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| A high-intensity interval exercise group | Other | — | UNRESOLVED |
| An Attention-Control Group | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- A high-intensity interval exercise group
- description
- Supervised exercise training with be carried out at the Mayo Clinic Cardiac rehabilitation center on cycle ergometers using EKG telemetry. Treatment will begin one week prior to chemotherapy and is tailored around 8 weeks.
- interventionNames
- Other: A high-intensity interval exercise group
- type
- OTHER
- label
- An attention-control group
- description
- Patients will receive counseling regarding physical activity during chemotherapy. Patients will receive a weekly phone call to maintain physical activity during chemotherapy and compliance will be verified using physical activity diaries and pedometers.
- interventionNames
- Other: An Attention-Control Group
Primary outcomes (2)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 40 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * Subjects must be able to communicate meaningfully with the investigator and must be legally competent to provide written informed consent * Subjects will have been recently diagnosed with breast cancer (stage I, II or III) * Subjects must be scheduled by their oncologist to undergo anthracycline based chemotherapy (doxorubicin and cyclophosphamide) in the neoadjuvant/adjuvant setting Exclusion Criteria: * Unstable angina * Myocardial infarction in the past 4 weeks * Uncompensated heart failure * New York Heart Association class IV symptoms * Complex ventricular arrhythmias * Medical orthopedic conditions precluding stationary cycling * Medical conditions precluding neuropsychological assessment * Symptomatic severe aortic stenosis * Acute pulmonary embolus * Acute myocarditis * Untreated high-risk proliferative retinopathy * Recent retinal hemorrhage * Uncontrolled hypertension * Sodium and/or Potassium ≥ Grade 2 * Pregnant Women
References
Publications (0)
Data not yet available