Study of Genetic and Cellular Immunological Parameters Predictive of Disease-free Survival in Patients With Metastatic Cancer

Inclusion Criteria:

For all patients:

* signed written informed consent

For cohort A:

* patient with metastatic colorectal cancer with first-line therapy by chemotherapy +/- surgery and with a disease-free survival \> or = at 20 months
* Ct-scan realized in the previous 4 weeks and showing no progression according to the Recist criteria v1.1

For cohort B:

* patient treated for metastatic colorectal cancer and chemotherapy responder (obtention of an objective response according to the Recist criteria V1.1 in first-line therapy), with a disease-free survival \< 10 months (disease progression must be confirmed by CT scan evaluation according to Recist v1.1 criteria)

For cohort C:

* patients with no metastatic rectum cancer in complete remission after chemotherapy and/or radiotherapy

For cohort D:

* patients with metastatic or locally advanced cancer in complete remission after treatment, non eligible in the other cohorts

Exclusion Criteria:

For all patients:

* patient with any medical or psychiatric condition or disease which would make the patient inappropriate for entry into this study
* patient with a neurodegenerative disease
* patient under guardianship, curator or under the protection of justice