Clinical trial · Observational
Genomic Analysis of Peritoneal Mesothelioma by CGH Arrays
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Peritoneal mesothelioma is a rare disease representing one third of all mesothelioma and nothing is known about molecular characteristics of this disease. As main cancers, genetic heterogeneity is probable. This genomic profiling associates Comparative Genomic Hybridization (CGH) array, BAP1 sequencing and gene expression in order to discover a biomarker that could be used in the treatment of this rare disease. Corresponding histopathological and immunohistochemical report as all clinical data are available. All data with be merged to underline a few genes of interest on which we will focus our next investigations. Depending of our preliminary results, BAP1 mutations are expected, as it was also described in pleural mesothelioma. Mutations in oncogenic drivers that could be targeted by specific therapy will be on particular interest in management of this rare disease with bad prognosis.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Peritoneal Mesothelioma | Peritoneal Mesothelial Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| comparative genomic analysis | Genetic | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Peritoneal mesothelioma specimens
- description
- The group harbors only patients who received the diagnosis of peritoneal mesothelioma after surgery. All patients are included in this group. The CGH arrays will be realized on frozen samples (for the comparative genomic analysis).
- interventionNames
- Genetic: comparative genomic analysis
Primary outcomes (1)
- measure
- BAP1 mutations
- timeFrame
- Day 0
- description
- CGH Array
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * surgical biopsy od the peritoneal tumor with frozen samples * age \> 18 years old Exclusion Criteria: * absence of peritoneal mesothelioma * absence of frozen samples
References
Publications (0)
Data not yet available