Clinical trial · Interventional
The Effect of Anesthetic Technique on VEGF-C and PGE2
Effect of Anesthetic Technique on Serum Vascular Endothelial Growth Factor C and Prostaglandin E2 in Women Undergoing Surgery for Uterine Leiomyomas
NCT02829333CI-TRIAL-00042907completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to verify the effect of anesthetic technique on the change of postoperative serum vascular endothelial growth factor C and prostaglandin E2, and to explore the potential impact of the anesthetic technique on leiomyomas recurrence and growth after the surgery of abdominal myomectomy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Uterine Leiomyomas | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| general anesthesia and patient controlled intravenous analgesia | Other | — | UNRESOLVED |
| spinal anesthesia and continuous postoperative epidural analgesia | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- OTHER
- label
- Group GA
- description
- 22 patients receive general anesthesia and patient controlled intravenous analgesia
- interventionNames
- Other: general anesthesia and patient controlled intravenous analgesia
- type
- OTHER
- label
- Group SA
- description
- 22 patients receive spinal anesthesia and continuous postoperative epidural analgesia
- interventionNames
- Other: spinal anesthesia and continuous postoperative epidural analgesia
Primary outcomes (2)
- measure
- Change of vascular endothelial growth factor C before anesthesia and at 48 hours after surgery
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * The patients with leiomyomas requiring abdominal myomectomy, aged 18-65 year and American Society of Anesthesiologists (ASA) physical status I or II. Exclusion Criteria: * The patients who had a history of surgery within the preceding two weeks, a history of blood transfusion and a history of coronary artery disease, any contraindication to spinal anesthesia or opioid analgesia.
References
Publications (0)
Data not yet available
No reference posted for this study.