Clinical trial · Interventional
Sulphate Accumulation in Prostate
A Pre-Biopsy Window of Opportunity Trial to Measure Sulphate Levels in Human Prostate After Broccoli Consumption
NCT02821728CI-TRIAL-00027967SAPcompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study evaluates whether a broccoli intervention (≥ 4 weeks) will result in differences in tissue sulphate levels in men scheduled for prostate biopsies. Comparisons will be made between participants randomised to the broccoli-rich diet and those randomised to the non-intervention arm.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Prostate Cancer | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dietary intervention | Dietary Supplement | — | UNRESOLVED |
| Normal diet | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Normal diet
- description
- No dietary intervention
- interventionNames
- Other: Normal diet
- type
- EXPERIMENTAL
- label
- Dietary intervention
- description
- 3 portions of broccoli soup per week
- interventionNames
- Dietary Supplement: Dietary intervention
Primary outcomes (1)
- measure
- Sulphate level
- timeFrame
- Biopsy on a single occasion at ≥ 4 weeks
- description
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Males * Scheduled for TPB as part of routine investigation or staging for prostate cancer * Aged 18-80 years * BMI between 19.5 and 35 kg/m2 * Smokers and non-smokers Exclusion Criteria: * Those regularly taking 5α-reductase inhibitors or testosterone replacement medicines * Those on warfarin treatment * Those diagnosed with diabetes * Those diagnosed with or suspected to be high-risk for human immunodeficiency virus (HIV) and/or hepatitis * Those allergic to any of the ingredients of the broccoli soups * Those taking dietary supplements or herbal remedies which may affect the study outcome. Please note that some supplements may not affect the study and this will be assessed on an individual basis * Those that are unable to understand English or give informed consent * Parallel participation in another research project that involves dietary intervention * Any person related to or living with any member of the study team
References
Publications (1)
- DERIVEDCoode-Bate J, Sivapalan T, Melchini A, Saha S, Needs PW, Dainty JR, Maicha JB, Beasy G, Traka MH, Mills RD, Ball RY, Mithen RF. Accumulation of Dietary S-Methyl Cysteine Sulfoxide in Human Prostate Tissue. Mol Nutr Food Res. 2019 Oct;63(20):e1900461. doi: 10.1002/mnfr.201900461. Epub 2019 Sep 11. PMID 31410992