Clinical trial · Interventional
Cardiac Tumors Interventional （Radio Frequency/Laser Ablation）Therapy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Currently, surgical removal remains the main clinical treatment for cardiac tumor patients. However, part of tumors are hard to completely resect. Also, as thoracoscopic surgeries induce great operation trauma, some patients cannot tolerate or do not will to take the operation. Therefore, new methods and techniques are in urgent need. Our center have a 12-year experience of intervention treatment for solid tumors and has conducted several animal experiments to verify the effectiveness of transthoracic puncture ablation and radiofrequency ablation for ventricular muscle. The purpose of this study is to conduct new method of direct transthoracic cardiac tumor-targeted Radiofrequency Ablation (RFA) or Laser induced Interstitial Thermotherapy (LITT), make minimally invasive treatment plans for cardiac tumor patients, and verify the safety and validity of intervention treatment in long term.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cardiac Tumors | Heart Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Direct Transthoracic Cardiac Tumor Laser Ablation Therapy | Procedure | — | UNRESOLVED |
| Direct Transthoracic Cardiac Tumor Radio Frequency Ablation Therapy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Cardiac tumors
- interventionNames
- Procedure: Direct Transthoracic Cardiac Tumor Radio Frequency Ablation Therapy
- Procedure: Direct Transthoracic Cardiac Tumor Laser Ablation Therapy
Primary outcomes (3)
- measure
- Mortality
- timeFrame
- 24 months
- measure
- Tumor size
- timeFrame
- 24 months
- description
- If the maximum tumor size increases, the symptom gets deteriorated; If the maximum tumor size decreases, the symptom gets relieved.
- measure
- Quantification of obstructive severity
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 12 Years
Show eligibility criteria text
Inclusion Criteria: * Cardiac tumors not suitable for surgical removal * Subject has significant clinical symptoms or obstruction (or progressive obstruction increase) in inflow or outflow tracts shown in imaging evidence * Cardiac tumors in ventricular chambers, myocardium, or pericardium * Subject who cannot tolerate thoracoscopic removal or volunteer for the operation * Subject Over 12 years old Exclusion Criteria: * Subject who has other cardiac diseases must receive surgical removal * Subject has end-stage heart failure * Subject has poor physical conditions and cannot tolerate the operation
References
Publications (1)
- DERIVEDHuang J, Lei C, Hsi DH, Zheng M, Ma H, Ta S, Hu R, Han C, Li W, Li J, Qu D, Ruan F, Wang J, Wang B, Zhao X, Liu J, Zhao L, Wang Z, Yang J, Liu L. Echocardiography-Guided Radiofrequency Ablation for Cardiac Tumors. JACC CardioOncol. 2024 Apr 30;6(4):560-571. doi: 10.1016/j.jaccao.2024.03.008. eCollection 2024 Aug. PMID 39239332