Clinical trial · Interventional
Effects of Total Intravenous Anesthesia With Propofol-remifentanil Versus Inhalational Anesthesia With Sevoflurane on Quality of Recovery in Patients Undergoing Transsphenoidal Surgery for Pituitary Tumor
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
A number of studies have compared the effects of total intravenous anesthesia(TIVA) versus inhalational anesthesia on perioperative period during transsphenoidal surgery. However, they have limitations especially for the phase of recovery after anesthesia: a fragmentary assessment. Quality of Recovery 40 (QoR-40) questionnaire was multi-dimensionally designed to assess the degree of recovery, specially after anesthesia and surgery. In this study, the investigators aim to compare the quality of recovery after inhalational anesthesia and after TIVA through QoR-40 questionnaire in patients undergoing transsphenoidal surgery for pituitary tumor under general anesthesia.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pituitary Tumor | Pituitary Gland Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| inhalation anesthesia group | Drug | — | UNRESOLVED |
| total intravenous anesthesia (TIVA) | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- TIVA group
- description
- Anesthesia is maintained with propofol during surgery
- interventionNames
- Drug: total intravenous anesthesia (TIVA)
- type
- ACTIVE_COMPARATOR
- label
- inhalation anesthesia group
- description
- Anesthesia is maintained with sevoflurane during surgery
- interventionNames
- Drug: inhalation anesthesia group
Primary outcomes (1)
- measure
- QoR-40 score
- timeFrame
- 1 day
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 19 Years
Show eligibility criteria text
Inclusion Criteria: * Patients over age 19 * Scheduled to undergo transsphenoidal surgery for pituitary tumor * ASA class I and II Exclusion Criteria: * Left ventricular ejection fraction \< 55% * Third-degree atrioventricular block * Second-degree atrioventricular block (P:QRS ratio of 3:1 or higher) * Fever * History of myocardial infarction, stroke or cardiac surgery within the previous 1 year * Severe neurological disease * Use of sedative, opioid or sleep-inducing drugs * Allergic history of any study drug * Pregnancy
References
Publications (1)
- BACKGROUNDAl-Shaikh B, George William M, Van Zundert AA. Using atmospheric pressure to inflate the cuff of the Portex Laryngeal Mask. Anaesthesia. 2005 Mar;60(3):296-7. doi: 10.1111/j.1365-2044.2005.04135.x. No abstract available. PMID 15710025