Clinical trial · Interventional
Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery
Effect of Deep Versus Moderate Neuromuscular Blockade on Peak Airway Pressures During Elective Laparoscopic Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a two period cross-over study randomizing patients undergoing laparoscopic surgery into 2 different groups: group 1 in which patients receive "deep neuromuscular blockade" in the beginning portion of their laparoscopic surgery followed by a period of "moderate blockade" and, group 2 in which patients receive "moderate neuromuscular blockade" in the beginning portion of their laparoscopic surgery followed by a period of "deep blockade". The deep neuromuscular block is defined as post tetanic count of 1 to 2 and the moderate neuromuscular block is defined as 1-2 twitches. In all patients, sugammadex is used to reverse the block at the end of surgery in order to obtain optimal extubating conditions.
Conditions
Conditions (7)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Bowel Obstruction | — | UNRESOLVED | — |
| Cholecystitis | — | UNRESOLVED | — |
| Chronic Kidney Disease | — | UNRESOLVED | — |
| Endometriosis | — | UNRESOLVED | — |
| Fibroids | Leiomyoma | ALIAS | 0.90 |
| Prostate Cancer | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
| Uterine Prolapse | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Deep to Moderate NMB | Procedure | — | UNRESOLVED |
| Moderate to Deep NMB | Procedure | — | UNRESOLVED |
| Rocuronium | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- OTHER
- label
- Deep to Moderate NMB
- description
- This group will undergo deep neuromuscular blockade, defined as post tetanic count (PTC) of 1 to 2, in the beginning portion of the surgery followed by a period of moderate blockade.
- interventionNames
- Procedure: Deep to Moderate NMB
- Drug: Rocuronium
- type
- OTHER
- label
- Moderate to Deep NMB
- description
- This group will undergo moderate neuromuscular blockade, defined as 1-2 twitches, in the beginning portion of the surgery followed by a period of deep blockade.
- interventionNames
- Procedure: Moderate to Deep NMB
- Drug: Rocuronium
Primary outcomes (1)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Each participant must be willing and able to provide written informed consent for the study. * Each participant must be American Society of Anesthesiologists (ASA) class I, II or III. * Each participant must be scheduled for elective laparoscopic surgery (this includes robotic laparoscopic surgery). * Expected surgical duration of 60 min or longer Exclusion Criteria: * Inability to give informed oral or written consent * Known or suspected neuromuscular disorders impairing neuromuscular function; * True allergies as defined as hypotension, bronchospasm, or anaphylaxis to muscle relaxants, anesthetics or opioids * A history (patient or family) of malignant hyperthermia * A contraindication for neostigmine administration * Renal insufficiency, as defined by serum creatinine levels at 2.5 fold the normal level * Body mass index \>40 kg/m\^2 * Significant respiratory disease. * Planned postoperative mechanical ventilation
References
Publications (0)
Data not yet available