Clinical trial · Interventional
Combined Training on Body Composition of Postmenopausal Women Undergoing Treatment for Breast Cancer
Effectiveness of Physical Training on Body Composition, Physical Activity Level and Quality of Life of Postmenopausal Women Undergoing Treatment for Breast Cancer With Aromatase Inhibitors: The Randomized Clinical Trial.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Breast cancer is a multifactorial disease affecting women, and one of the treatments for its healing and survival is hormone therapy. Aromatase inhibitors are third-generation drugs that promote lower chance of metastasis, but their side effects include the loss of bone mineral density and increased fat percentage. In this way, the Combined Training (combined resistance and endurance training) may be an interesting strategy to minimize the side effects of aromatase inhibitors, providing better quality of life, survival and changes in body composition.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Aromatase Inhibitors | — | UNRESOLVED | — |
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Postmenopausal | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Combined Training | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- NO_INTERVENTION
- label
- Group Control with breast cancer and without breast cancer
- description
- Stretching exercises, lasting 40 minutes each session, 2 times a week for nine months
- type
- EXPERIMENTAL
- label
- Combined Training with breast cancer and without breast cancer
- description
- Combined Training: 36 weeks duration, 3 times a week on nonconsecutive days. The combined training program lasts 70 minutes per session, with 40 minutes of resistance training and 30 minutes of aerobic training.
- interventionNames
- Behavioral: Combined Training
Primary outcomes (1)
- measure
- Chance from Body composition at 9 months assessment by bone densitometry (Dual-energy x-ray absorptiometry), using the equipment model GE Lunar - DPX-NT
- timeFrame
- At baseline, 3, 6 and 9 months timepoint
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 50 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Postmenopausal, defined by the absence of periods for the past 12 months; * Breast cancer diagnosis stages 1 to 3; * The adjuvant treatment for breast cancer and / or neoadjuvant aromatase inhibitors * No abnormalities on screening physical or any health problems that contraindicate study participation; * No contraindications for treadmill testing or entry into a training program, including any of the following: * Myocardial infarction within the past 6 months * Pulmonary edema * Myocarditis Pericarditis * Unstable angina * Pulmonary embolism or deep vein thrombosis * Uncontrolled hypertension (i.e., blood pressure \> 200/100 mm Hg) * Uncontrolled arrhythmia * No significant mental illness * Have medical certificate to perform exercise testing and participate in combined training * Able to answer Questionnaires * No concurrent participation in any other organized exercise program; * Live in Presidente Prudente * Sign the consent form and formal clarification for participation in the study. Exclusion Criteria: * Accumulating 3 unexcused absences or 4 consecutive unexcused absences during the month.
References
Publications (1)
- DERIVEDFelipe J, Viezel J, Reis AD, da Costa Barros EA, de Paulo TRS, Neves LM, Junior IFF. Relationship of different intensities of physical activity and quality of life in postmenopausal women. Health Qual Life Outcomes. 2020 May 6;18(1):123. doi: 10.1186/s12955-020-01377-1. PMID 32375779