Clinical trial · Observational
Assessment of Postoperative Lymphopenia as Risk Factor for Postoperative Infections
Assessment of Postoperative Lymphopenia as Risk Factor for Postoperative Infections: EVALYMPH Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Postoperative infections are one of the most common complications in thoracic and digestive cancer surgery. Former studies have demonstrated that inflammatory response is altered during peri-operative period causing lymphopenia. It has been suggested that lymphopenia may contribute to postoperative infection. To date, no one has proved it in a multivariate analysis. The aim of this study is to determine if lymphopenia is associated with postoperative infections in thoracic and digestive cancer surgery.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer of the Digestive System | Malignant Digestive System Neoplasm | ALIAS | 0.90 |
| Thoracic Diseases | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Collection of plasma cell rate | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Collection of plasma cell rate
- description
- Post operative infections and their association with lymphopenia are assessed in this study for patients over 18 years of age undergoing digestive or thoracic cancer surgery under general anesthesia.
- interventionNames
- Other: Collection of plasma cell rate
Primary outcomes (1)
- measure
- Presence of post operative infection
- timeFrame
- 1 month
- description
- Patients undergoing general anesthesia for thoracic or digestive surgery could present lymphopenia. In this situation, the presence of post operative infection is notified. The correlation between lymphopenia and post operative infections is studied.
Secondary outcomes (1)
- measure
- Anesthetic and surgical parameters
- timeFrame
- 1 month
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * patient undergoing digestive or thoracic cancer surgery under general anesthesia. Exclusion Criteria: * pregnant women, * malignant blood disease, * allograft patient, * preoperative sepsis or preoperative systemic inflammatory response syndrome.
References
Publications (1)
- DERIVEDPetit L, Pastene B, Dupont G, Baffeleuf B, Goulevant PA, Fellahi JL, Gricourt Y, Lebuffe G, Ouattara A, Fischer MO, Mertes PM, Eyraud D, Bouhemad B, Gomola A, Montravers P, Alingrin J, Flory L, Incagnoli P, Boisson M, Leone M, Monneret G, Lukaszewicz AC, Pereira B, Molliex S; for the EVALYMPH study group. Postoperative lymphopaenia as a risk factor for postoperative infections in cancer surgery: A prospective multicentre cohort study (the EVALYMPH study). Eur J Anaesthesiol. 2025 Mar 1;42(3):244-254. doi: 10.1097/EJA.0000000000002089. Epub 2024 Oct 29. PMID 39474711