Clinical trial · Observational
Food Reward in Cachexia Induced by Acute or Chronic Disease
Analysis of Food Reward System in Cachexia Induced by Acute or Chronic Disease
NCT02798003CI-TRIAL-00079502terminatedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Not feasible to include the needed patients
Summary
Brief summary (as posted)
To study activity in the reward-circuitry of the brain in patients suffering from cachexia induced by cancer or chronic disease.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cachexia | — | UNRESOLVED | — |
| Chronic Obstructive Pulmonary Disease | — | UNRESOLVED | — |
| Non-small Cell Lung Cancer | Lung Non-Small Cell Carcinoma | ALIAS | 0.90 |
| Pancreatic Cancer | Malignant Pancreatic Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Functional magnetic resonance imaging (fMRI) | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- label
- Cachectic cancer patients
- description
- Cachectic cancer patients, including non-small cell lung cancer (NSCLC) and gastro-intestinal cancer. The study participants will undergo fMRI scanning.
- interventionNames
- Other: Functional magnetic resonance imaging (fMRI)
- label
- Non-cachectic cancer patients
- description
- Non-cachectic cancer patients, including NSCLC and gastro-intestinal cancer. The study participants will undergo Functional magnetic resonance imaging (fMRI) scanning.
- interventionNames
- Other: Functional magnetic resonance imaging (fMRI)
- label
- Cachectic COPD patients
- description
- Diagnosis of Chronic Obstructive Pulmonary Disease (COPD) consistent with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria. The study participants will undergo fMRI scanning.
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * For cachectic patients: weight loss exceeds 5% of total body weight over the past 6 months, or \>2% when body mass index is \<20 kg/m2 * For non-cachectic patients: no weight loss of ≥5% during the last 6 months * Non-small cell lung cancer or gastro-intestinal cancer, pathology proven or diagnosis of COPD consistent with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria Exclusion Criteria: * Contra-indications for fMRI examination (operation to your head or brain in the past; implanted electronic devices, for instance a pacemaker, neurostimulator, cochlear or hearing implant; insulin pump under your skin; Pregnant subjects, claustrophobia; pregnancy; metal parts in your body (except from teeth filling and connectors): implants; brain vessel clamps, prostheses, intra-uterine device, metal splinter in the eye, metal braces or other metal objects, permanent eye make-up) * Psychiatric or other disorders likely to impact on informed consent * Presence of brain metastasis (screening is not mandatory) * Medical history of cerebrovascular accident, brain tumour, brain metastasis * Previous radiotherapy to brain, both stereotactic and whole brain radiotherapy * Memory problems * Current use of tube feeding or parental nutrition * Patients with an active second malignancy * Patients unable to lie still for 2 hours * Unable to complete the cognitive task * Pre-existing swallowing difficulties * Allergy to gluten-, milk- or wheat products * Self-reported hyperthyroidism * Self-reported diabetes mellitus * Current use of appetite stimulant medications
References
Publications (0)
Data not yet available
No reference posted for this study.