Clinical trial · Interventional
Effect of Iranian Traditional Medicine Remedy on Chemotherapy Induced Nausea and Vomiting
ٍEffect of Iranian Traditional Medicine Remedy Compared With Placebo on Chemotherapy Induced Nausea and Vomiting in Breast Cancer; a Double-blind Randomized Controlled Cross-over Clinical Trial
NCT02787707CI-TRIAL-00022481completedPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The main objective of this research is the role of the Persumac(an Iranian traditional remedy) on refractory Chemotherapy Induced Nausea and Vomiting (CINV) in breast cancer patients. Investigators assess effect of Persumac on the number/severity of nausea/ vomiting in acute and delayed phase.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Nausea | — | UNRESOLVED | — |
| Vomiting | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| lactose | Drug | — | UNRESOLVED |
| Persumac | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- intervention
- description
- 2.7 grams Persumac powder (Iranian traditional medicine remedy composed from sumac and Bunium Persicum) every 8 hour from 24 hour before to fifth day after chemotherapy.
- interventionNames
- Drug: Persumac
- type
- PLACEBO_COMPARATOR
- label
- control
- description
- 2.7 grams Lactose every 8 hour from 24 hour before to fifth day after chemotherapy.
- interventionNames
- Drug: lactose
Primary outcomes (1)
- measure
- Frequency and Severity of nausea and vomiting in acute phase
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion criteria: * Clinical diagnosis of breast cancer, * Clinical diagnosis of chemotherapy induced nausea and vomiting resistant to conventional therapy. Exclusion Criteria: * Clinical diagnosis of hypersensitivity to Sumac or Bunium Persicum, * Clinical diagnosis of digestion disorders, * Clinical diagnosis of non chemotherapy induced nausea and vomiting, * Milk allergy, * Clinical diagnosis of bleeding diathesis, * Clinical diagnosis of non-breast cancer.
References
Publications (1)
- DERIVEDNazari M, Taghizadeh A, Bazzaz MM, Rakhshandeh H, Shokri S. Effect of Persian Medicine Remedy on Chemotherapy Induced Nausea and Vomiting in Breast Cancer: A Double Blind, Randomized, Crossover Clinical Trial. Electron Physician. 2017 Jan 25;9(1):3535-3543. doi: 10.19082/3535. eCollection 2017 Jan. PMID 28243404