Clinical trial · Interventional
Effect of Iloprost on Pulmonary Oxygenation in Patients With Low Diffusing Capacity During One-lung Ventilation
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
One lung ventilation (OLV) is essential during thoracic surgery. During OLV, intrapulmonary shunt can be increased resulting hypoxemia. Although OLV technique had been advanced so far, hypoxemia during OLV reaches about 10% in spite of inspired oxygen fraction 100%. Iloprost is a prostaglandin analogue used for pulmonary hypertension, which can decrease pulmonary artery resistance by selectively dilating pulmonary artery. In this prospective, randomized, double blind study, investigators are planning to investigate the effects of iloprost on respiratory physiology (intrapulmonary shunt, deadspace, oxygenation, etc).
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| iloprost | Drug | — | UNRESOLVED |
| normal saline | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- iloprost group
- description
- iloprost inhalation group
- interventionNames
- Drug: iloprost
- type
- PLACEBO_COMPARATOR
- label
- control group
- description
- normal saline inhalation group
- interventionNames
- Drug: normal saline
Primary outcomes (2)
- measure
- PaO2(partial pressure of arterial oxygen) ratio
- timeFrame
- 40 minutes after iloprost inhalation
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 40 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * scheduled for Video-assisted thoracoscopic surgery (VATS) lobectomy * 40 \< age \< 80 * American Society of Anaesthesiologists (ASA) physical status classification I\~III * diffusing capacity (DLCO) \<75% at pre op. pulmonary function test Exclusion Criteria: * American Society of Anaesthesiologists (ASA) physical status classification IV * New York Heart Association (NYHA) class III\~IV * Severe obstructive lung disease and/or restrictive lung disease patients * patients with end-organ diseases (i.e. heart failure, respiratory failure, hepatic failure, renal failure) * arrhythmia * pregnant women * disease that can influence the DLCO result (anemia, pulmonary vascular disease)
References
Publications (0)
Data not yet available