Sexual Steroids: Relationship Between Serum and Prostatic Tissue Level

Patients followed in the Foch Hospital Urology Department (Suresnes): Patients justifying a prostatectomy. * Patients justifying prostatectomy together with the bladder (radical cystectomy for bladder cancer). * Patients with benign prostate hyperplasia who justified a prostatectomy. Compare serum sexual steroid concentrations and intra-tissue on healthy prostates and prostate adenoma, assess concentrations intra-tissue sex steroids on cancer metastasis prostate specific blood sample under study (30mL) will be performed preoperatively in Patients followed in Foch Hospital Urology Department (Suresnes), and a Removal of a fragment of prostate tissue or metastasis will be analyze. Aim is to compare serum concentrations of sexual steroids and intra-tissue on healthy prostates and prostate adenomas compared to concentrations measured in patients operated for prostate cancer.

Sex

Male

Minimum age

18 Years

Inclusion Criteria:

* Men aged over 18 years
* Surgical indication justifying protatique prostatectomy, or complete prostatocystectomie, or removal of a metastasis of prostate cancer.
* Patients affiliated to a social security scheme or benefiting from such a regime.
* Patients who have given their consent to participate in writing

Exclusion Criteria:

* Patient received local therapy or hormonal treatment (LHRH analogue, therapy blocking androgen receptors) before surgery.
* Treatment reductase inhibitors 5ARI ongoing or stopped for less than 3 months before the intervention.
* Patient included in another clinical trial inconsistent with the conduct of this research.
* Patient receiving treatment that could interfere with hormone levels (Prednisone, Ketoconazole, Abiraterone, Finasteride, Dutasteride).