Clinical trial · Observational
A Gene Hunting Study for Familial Papillary Thyroid Cancer
A Strategy to Search for Genes Predisposing to Papillary Carcinoma of the Thyroid When Mutated
NCT02776969CI-TRIAL-00096262active not recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of this project is to identify genetic risk factors associated with familial papillary thyroid carcinoma (PTC). Papillary thyroid cancer is a type of cancer that shows high heritability. However, the specific genetic factors that cause an increased risk have been elusive.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Thyroid | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Genetic variants associated with familial papillary thyroid cancer as assessed by multiple genetic testing methodologies
- timeFrame
- Up to 5 years
- description
- Variants will be assessed for segregation within families, expression in the normal thyroid and/or thyroid cancer, and functional significance
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with a diagnosis of PTC and a family history of PTC in 3 or more living relatives * Affected and unaffected family members of the proband\* * For familial cases (families with 4 or more cases of PTC), participation will be offered to all living family members with PTC or benign thyroid disease as well as selected unaffected first and second degree relatives. Participation may also be offered to spouses when needed for analyzing parent/offspring samples. Exclusion Criteria: * Known germline predisposition (ex: pathogenic PTEN variant) * Non-English speaking
References
Publications (0)
Data not yet available
No reference posted for this study.