Clinical trial · Observational
Advanced Perfusion MRI of Treatment Response and Progression in Glioblastoma
NCT02769806CI-TRIAL-00063258terminatedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): funding
Summary
Brief summary (as posted)
The primary aim of this project is to Compare new msCS and standard DSC-PWI methods in GBM patients undergoing post-operative MRI for monitoring of tumor progression.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Glioblastoma | Glioblastoma | CURATED_BROADER | 0.80 |
| Glioblastoma Multiforme | Glioblastoma | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| MRI | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- GBM patients undergoing MRI
- description
- GBM patients undergoing standard-of-care post-operative combination chemoRT and clinically indicated MRI including standard DSC-PWI for follow-up.
- interventionNames
- Procedure: MRI
Primary outcomes (1)
- measure
- A novel high resolution DSC-PWI imaging method
- timeFrame
- 2 years
- description
- A novel high resolution DSC-PWI method will be compared to the standard DSC-PWI method to determine whether novel method improves image quality in tumor regions.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 82 Years
Show eligibility criteria text
Inclusion Criteria: * Histology: Glioblastoma (grade 4 astrocytoma) * Standard-of-care, post-gd T1w image changes suggestive or consistent with of progression. * Standard-of-care MRI included conventional DSC-PWI without unexpected technical difficulties. * Methylation status of tumor available in medical record. * Able to provide written informed consent. Exclusion Criteria: * Contraindications either to 3T MRI (e.g. certain metallic and electronic implants, claustrophobia) or IV gadolinium contrast (allergy, pregnancy, breast-feeding, renal insufficiency). Screening for these contraindications will be based on history only (as it is for all routine outpatient clinical MRI at UWHC). * Significant physical or mental disease which would preclude successful compliance and participation in the study or, in the opinion of the principal investigator, or co-investigator, constitute a hazard, such that enrollment in the study would not be in the patient's best interest. * Special subjects such as minors, mentally disabled persons, or prisoners.
References
Publications (0)
Data not yet available
No reference posted for this study.