Clinical trial · Interventional
Physical Activity Intervention to Reduce Functional Health Disparities Among Breast Cancer Survivors
A Physical Activity Intervention to Reduce Functional Health Disparities Among Older Breast Cancer Survivors
NCT02763228CI-TRIAL-00057247completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this research study is to determine whether a physical activity (exercise) program in the community will improve the functional and overall health status of older women with a history of breast cancer. The physical activity or exercise program is designed for all older breast cancer survivors, and in particular for African-Americans and women of lower socio-economic status, who are the least likely to engage in physical activity.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Physical Activity | — | UNRESOLVED | — |
Interventions
Interventions (7)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Aerobic Training - Fixed Schedule | Behavioral | — | UNRESOLVED |
| Aerobic Training - Flexible Schedule | Behavioral | — | UNRESOLVED |
| Flexible support groups | Behavioral | — | UNRESOLVED |
| Resistance Training - Fixed Schedule | Behavioral | — | UNRESOLVED |
| Resistance Training - Flexible Schedule | Behavioral | — | UNRESOLVED |
| Successful Survivorship Health Education and Support Group | Behavioral | — | UNRESOLVED |
| Walking program | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Group 1: Exercise Program
- description
- The exercise in this study will consist of two types of exercise training: resistance training and aerobic exercise. Resistance training is like "weight lifting" to improve strength and function. Participants will complete resistance training by using resistance machines and free weights. Aerobic exercise is exercise that intends to improve the cardiopulmonary or oxygen/lung and heart systems. It is often referred to as "cardio" exercise. Treadmill walking, stationary cycling sessions, and/or other exercises will be used for aerobic exercise. Participants will be instructed in the exercise routine by physical fitness experts and trainers.
- interventionNames
- Behavioral: Aerobic Training - Fixed Schedule
- Behavioral: Resistance Training - Fixed Schedule
- Behavioral: Walking program
- Behavioral: Aerobic Training - Flexible Schedule
- Behavioral: Resistance Training - Flexible Schedule
- type
- ACTIVE_COMPARATOR
- label
- Group 2: Support Group
- description
- First 20 Weeks: Participants will take part in a structured Health Education and Support Group sessions once a week. Last 32 weeks: Participants will be encouraged to take part in any of the Support Group sessions offered regularly on their own schedule.
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Pathologically confirmed breast cancer * Stage I-III * Patients who have completed treatment but are within five years of treatment completion (primary surgery, chemotherapy or radiation therapy), whichever was received last. Hormonal therapy and targeted therapy are allowed * Race: African-Americans and Non-Hispanic Whites Exclusion Criteria: * Stage IV breast cancer * Patients with end-stage disease, severe dementia and/or life expectancy of less than one year * Inability to understand English as study instruments have not been validated in other languages * Inability to provide informed consent * High-risk patients (as defined by the American College of Sports Medicine risk-stratification schema using the American College of Sports Medicine (ACSM)/American Heart Association exercise pre-participation questionnaire) who do not receive clearance from cardiology * Other medical or psychological conditions that would make participation unsafe or inhibit our ability to test our primary hypothesis, e.g. Parkinson's disease, severe dementia.
References
Publications (3)
- DERIVEDHundal J, Williams D, Nock NL, Austin K, Bennet E, Cerne S, Moore HCF, Petkac J, Schmitz KH, Berger NA, Owusu C. Older breast cancer survivors' exercise and support group program experiences and recommendations from the IMPROVE trial: a qualitative study. BMC Cancer. 2026 Jan 6;26(1):181. doi: 10.1186/s12885-025-15425-w. PMID 41495697
- DERIVEDOwusu C, Margevicius S, Nock NL, Austin K, Bennet E, Cerne S, Hergenroeder P, Moore HCF, Petkac J, Schluchter M, Schmitz KH, Webb Hooper M, Wimbley L, Berger NA. A randomized controlled trial of the effect of supervised exercise on functional outcomes in older African American and non-Hispanic White breast cancer survivors: Are there racial differences in the effects of exercise on functional outcomes? Cancer. 2022 Jun 15;128(12):2320-2338. doi: 10.1002/cncr.34184. Epub 2022 Mar 15. PMID 35289926
- DERIVEDOwusu C, Nock NL, Feuntes V, Margevicius S, Hergenroeder P, Austin K, Bennet E, Cerne S, Moore HCF, Petkac J, Schluchter M, Schmitz KH, Webb Hooper M, Coccia S, Nagy C, Wimbley L, Berger NA. IMPROVE, a community-based exercise intervention versus support group to improve functional and health outcomes among older African American and Non-Hispanic White breast cancer survivors from diverse socioeconomic backgrounds: Recruitment strategies and baseline characteristics. Cancer. 2021 Jun 1;127(11):1836-1846. doi: 10.1002/cncr.33430. Epub 2021 Feb 4. PMID 33539554