Clinical trial · Interventional
SvO2 Trigger in Transfusion Strategy After Cardiac Surgery
Restrictive Transfusion Strategy Early After Cardiac Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Current international guidelines suggest a restrictive transfusion strategy, setting that Hb level at 7 g/dl is a reasonable threshold. However, the idea of having only one threshold for all the patients has been challenged by authors, suggesting a more liberal strategy for certain cases. At the moment, there is no other parameter considered accurate enough to be taken into consideration for transfusion strategy management. This study is to use ScVO2, a current, easily accessible parameter, before blood transfusion in order to stratify its indication after cardiac surgery. Monocentric, randomised, single blind study (patient not aware of the group assignments) Patient inclusion will be made in ICU if the physician decides to perform blood transfusion according to standard transfusion strategy to treat a postoperative anemia (Hb\<9g/dL). Every patient will go through randomization to be placed in one of the two groups of the study: either the one whose transfusion strategy is adjusted by the pretransfusion ScvO2 (group ScvO2), or the control group. Our main objective is to evaluate the impact of a new transfusion strategy founded on guidelines, but provided ScvO2 is less than 65%, on the incidence of red blood cells transfusion for anemia early after cardiac surgery.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anemia (<9g/dL) Requiring Blood Transfusion | — | UNRESOLVED | — |
| Bleeding Graded as Insignificant, Mild, Moderate of Universal Definition of Perioperative Bleeding | — | UNRESOLVED | — |
| Central Venous Catheter on the Superior Vena Cava (to Perform ScVO2 Measure) | — | UNRESOLVED | — |
| Hemodynamic and Respiratory Stability | — | UNRESOLVED | — |
| Undergoing Nonemergent Cardiac Surgery | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Red blood cell tranfusion | Other | — | UNRESOLVED |
| ScvO2 measure | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- ScVO2 group
- description
- Anemia (\<9g/dL) requiring blood transfusion Measure of ScvO2 : ScVO2 is measured using the central venous catheter placed in the superior vena cava. Transfusion is performed if the ScVO2 is inferior or equal to 65%.
- interventionNames
- Other: ScvO2 measure
- type
- OTHER
- label
- Control group
- description
- Anemia (\<9g/dL) requiring blood transfusion : Transfusion is performed following national guidelines for red blood cell transfusion
- interventionNames
- Other: Red blood cell tranfusion
Primary outcomes (1)
- measure
- Number of patients transfused
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 100 Years
Show eligibility criteria text
Inclusion Criteria: * Age over 18 years * Patients admitted to intensive care after heart surgery * Anemic patient (Hb \< 9 g/dL) * Patient with a central venous catheter in the territory SVC Exclusion Criteria: * Patient with acute bleeding defined as a postoperative bleeding over 1000 ml in 12 hours or the need for a recovery operation for hemostasis or the transfusion of blood units over 4 * Patient with severe sepsis or septic shock criteria defined by the Surviving Sepsis compaign
References
Publications (1)
- RESULTZeroual N, Blin C, Saour M, David H, Aouinti S, Picot MC, Colson PH, Gaudard P. Restrictive Transfusion Strategy after Cardiac Surgery. Anesthesiology. 2021 Mar 1;134(3):370-380. doi: 10.1097/ALN.0000000000003682. PMID 33475735