Clinical trial · Interventional
Can Dietary Phytoestrogens Slow Down Prostate Tumor Proliferation?
Can Dietary Phytoestrogens Slow Down Prostate Tumor Proliferation? A Randomized Study (PRODICA)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to evaluate if a diet with a high content of phytoestrogens can slow down the prostate tumor proliferation. Phytoestrogens are found in food items such as soy, rye, and seeds. Two hundred thirty men with prostate cancer will be included in the study and followed until surgery (at least 6 weeks). Half of the study participants will receive general information about healthy food choices and a package of foods with high content of phytoestrogens to add to their food. The other half will get the same information but not receive the food-package.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Prostate Cancer | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Phytoestrogen-rich foods | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Phytoestrogen-rich foods
- description
- * Introduced to the study by a dietitian. * Receive general information about healthy food choices (according to the Swedish National Food Agency's recommendations for the general public). * Be told not not to eat any dietary supplements, though no other dietary restrictions will be given. * Called one time during the study and perform a 24-hour recall. * The intervention continues until the day before the surgery (at least 6 weeks). * The patients in the experimental group will be given a package containing food with a high amount of phytoestrogens.
- interventionNames
- Other: Phytoestrogen-rich foods
- type
- NO_INTERVENTION
- label
- Control group
- description
- * Introduced to the study by a dietitian. * Receive general information about healthy food choices (according to the Swedish National Food Agency's recommendations for the general public). * Be told not not to eat any dietary supplements, though no other dietary restrictions will be given. * Called one time during the study and perform a 24-hour recall. * The intervention continues until the day before the surgery (at least 6 weeks).
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- Male
Show eligibility criteria text
Inclusion Criteria: * men in the Västra Götaland healthcare region * diagnosed with prostate cancer of intermediate risk-level (T1-T2, Gleason score \<8 and PSA\<20) * scheduled for radical prostatectomy Exclusion Criteria: * ongoing hormonal treatment. * other difficult physical or psychological conditions * diminished cognitive function * allergy to soy * having taken dietary supplements regularly (daily) during the preceding three months * does not understand written Swedish
References
Publications (1)
- DERIVEDAhlin R, Nybacka S, Josefsson A, Stranne J, Steineck G, Hedelin M. The effect of a phytoestrogen intervention and impact of genetic factors on tumor proliferation markers among Swedish patients with prostate cancer: study protocol for the randomized controlled PRODICA trial. Trials. 2022 Dec 21;23(1):1041. doi: 10.1186/s13063-022-06995-2. PMID 36544211