Clinical trial · Observational
Procalcitonin Reveals Early Dehiscence in Pancreatic Surgery: the PREDIPS Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Background. Pancreatic cancer surgery is associated with very high risk of postoperative morbidity and mortality. Anastomotic leak (AL) is one of the worst complications associated with relevant short and long-term sequelae. Procalcitonin (PCT) is a biomarker used to monitor bacterial infections and guide antibiotic therapy and has been shown to have better predictive value of AL after colorectal surgery than C-reactive protein (CRP) and white blood cell count (WBC). Purpose. The investigators designed a monocentric pilot study to test if PCT might be a sensitive and reliable marker of AL after pancreatic surgery
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pancreatic Cancer | Malignant Pancreatic Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| pts operated for pancreatic cancer | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- pts operated for pancreatic cancer
- description
- all pts operated of pancreatic resection for cancer in the involved units
- interventionNames
- Other: pts operated for pancreatic cancer
Primary outcomes (2)
- measure
- Sensitivity of PCT and CRP for anastomotic leak (AL) after pancreatic surgery
- timeFrame
- 2 yrs
- description
- Sensitivity: % of patients corrected identified by the biomarkers having AL; PCT: procalcitonin, CRP: C-reactive protein, AL: anastomic leak
- measure
- Specificity of PCT and CRP for anastomotic leak (AL) after pancreatic surgery
- timeFrame
- 2 yrs
- description
- Specificity: % of pts corrected identified by the biomarkers not having AL; PCT: procalcitonin, CRP: C-reactive protein, AL: anastomic leak
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 100 Years
Show eligibility criteria text
Inclusion Criteria: * patients undergoing all different kinds of pancreatic surgery * in elective setting * for cancer * with a pancreatic anastomosis performed. Exclusion Criteria: * age \< 18 years * pregnant women * patients undergoing pancreatic surgery for benign disease, other kinds of pancreatic surgery without an anastomosis being performed
References
Publications (0)
Data not yet available