Clinical trial · Observational
Procalcitonin Reveals Early Dehiscence in Gastric Surgery: the PREDIGS Study
Procalcitonin Reveals Early Dehiscence In Gastric Surgery: the PREDIGS Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Background. Gastric cancer surgery is associated with high risk for postoperative morbidity and mortality. Anastomotic leak (AL) is one of the worst complications associated with relevant short and long-term sequelae. Procalcitonin (PCT) is a biomarker used to monitor bacterial infections and guide antibiotic therapy and has been shown to have better predictive value of AL after colorectal surgery than C-reactive protein (CRP) and white blood cell count (WBC). Purpose. Investigators designed a monocentric pilot study to test if PCT might be a sensitive and reliable marker of AL after gastric surgery
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gastric Cancer | Malignant Gastric Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| gastric cancer pts undergoing surgery | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- gastric cancer pts undergoing surgery
- description
- all pts receiving gastric resection for cancer, with anastomosis
- interventionNames
- Other: gastric cancer pts undergoing surgery
Primary outcomes (2)
- measure
- % of patients with leaks after gastric surgery correctly identified by the biomarkers (PCT and CRP)
- timeFrame
- 2 years
- description
- PCT: procalcitonin, CRP: C-reactive protein
- measure
- % of patients without leaks after gastric surgery correctly identified by PCT and CRP
- timeFrame
- 2 years
- description
- PCT: procalcitonin, CRP: C-reactive protein
Secondary outcomes (2)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 100 Years
Show eligibility criteria text
Inclusion Criteria: * patients undergoing all different kinds of gastric surgery (from partial to total gastrectomy) for cancer, WITH an anastomosis performed * elective setting Exclusion Criteria: * age \< 18 years * pregnant women * patients undergoing gastric surgery for benign disease or other kinds of gastric surgery without an anastomosis being performed
References
Publications (0)
Data not yet available