Clinical trial · Observational
Endocan, VEGF and TNF-alpha Levels in Periodontal Disease and After Treatment
Effect of Non-surgical Periodontal Treatment on Gingival Crevicular Fluid and Serum Endocan, Vascular Endothelial Growth Factor-A and Tumor Necrosis Factor Alpha Levels
NCT02750956CI-TRIAL-00021922completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The primer aim of the study was to determine serum and gingival crevicular fluid (GCF) endocan levels in periodontal diseases pathogenesis supported with vascular endothelial growth factor (VEGF) and tumor necrosis factor alpha (TNF-α) levels.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Periodontal Disease | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Non-surgical periodontal treatment | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- Group 1
- description
- Periodontal healthy individuals
- label
- Group 2
- description
- Patients with chronic periodontitis
- interventionNames
- Procedure: Non-surgical periodontal treatment
- label
- Group 3
- description
- the same patients in group 2 after they had been treated with scaling and root planing (SRP) were considered as Group 3.
- interventionNames
- Procedure: Non-surgical periodontal treatment
Primary outcomes (1)
- measure
- Endocan levels
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 25 Years
- Maximum age
- 49 Years
Show eligibility criteria text
Group 1 Inclusion Criteria: * No bone and attachment loss, * GI=0, PPD≤3mm, CAL≤3mm * Systematically healthy patients Group 2 Inclusion Criteria: * GI\>1, PPD≥5mm, CAL≥5mm with alveolar bone loss radiographically. * Systematically healthy patients Exclusion Criteria: * Aggressive Periodontitis, * Oral pathologies, * Patients with any other systemic diseases, * Pregnant women and those in the lactation period, * Patients with smoking habit and taking medication * Patients received periodontal therapy in last 6 months
References
Publications (0)
Data not yet available
No reference posted for this study.