Clinical trial · Interventional
Effect of Irradiation of the Cavernous Sinus and the Sellar Region on Autobiographical Memory
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Several studies showed that radiotherapy as brain tumors treatment may affect cognition. It was observed that durable memory impairments could arise at irradiated patients if radiotherapy is applied on medial temporal lobes. However, results concerned studies of anterograde memory and none, this day, estimates the impact of radiotherapy on autobiographical memory which also involves hippocampus. The aim of this study is to evaluate effects of cavernous sinus or sellar region irradiation on autobiographical memory. Thirty 35 to 65 years old patients, with cavernous sinus meningioma or pituitary adenoma for who radiotherapy is indicated will be recruited.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cavernous Sinus Meningioma | Cavernous Sinus Meningioma | ONTOLOGY_EXACT | 0.98 |
| Pituitary Adenoma | Pituitary Neuroendocrine Tumor | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Evaluation of autobiographical memory | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Patients with brain tumors treated by radiotherapy
- description
- Patients with: \- meningioma of the cavernous sinus for which radiotherapy is planned Or \- a pituitary adenoma for which radiotherapy is planned
- interventionNames
- Other: Evaluation of autobiographical memory
Primary outcomes (1)
- measure
- Autobiographical memory test (TEMPau) score
- timeFrame
- Two years after irradiation treatment end
Secondary outcomes (4)
- measure
- Autobiographical memory test (TEMPau) score
- timeFrame
- One year after irradiation treatment end
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 35 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Age between 35 and 65. * Patient with: * meningioma of the cavernous sinus for which radiotherapy is planned * or a pituitary adenoma for which radiotherapy is planned * French Mother tongue * Person affiliated to national insurance * Person who give its verbal agreement to participate Exclusion Criteria: * Presence of a serious psychiatric disorder (major depression, psychotic disorders, etc.) and central nervous system disease (epilepsy, multiple sclerosis, etc.). * Treatment with chemotherapy * General intellectual abilities deficient (IQ \<80) * Extension front of their meningioma * Deficient Language Skills.
References
Publications (4)
- BACKGROUNDNadel L, Moscovitch M. Memory consolidation, retrograde amnesia and the hippocampal complex. Curr Opin Neurobiol. 1997 Apr;7(2):217-27. doi: 10.1016/s0959-4388(97)80010-4. PMID 9142752
- BACKGROUNDCabeza R, St Jacques P. Functional neuroimaging of autobiographical memory. Trends Cogn Sci. 2007 May;11(5):219-27. doi: 10.1016/j.tics.2007.02.005. Epub 2007 Mar 26. PMID 17382578
- BACKGROUNDMizumatsu S, Monje ML, Morhardt DR, Rola R, Palmer TD, Fike JR. Extreme sensitivity of adult neurogenesis to low doses of X-irradiation. Cancer Res. 2003 Jul 15;63(14):4021-7. PMID 12874001
- RESULTSans C, Dupin C, Huchet A, Branchard O, Nunes ML, Vendrely V, Loiseau H, Planchon C. [Prospective longitudinal study on the evolution of autobiographical memory in patients irradiated for benign skull base tumour]. Cancer Radiother. 2024 Aug;28(4):309-316. doi: 10.1016/j.canrad.2023.11.003. Epub 2024 Jun 24. French. PMID 38918132