Clinical trial · Observational
Social Cognition and Brain Integrity in Survivors of Pediatric Medulloblastoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Survivors of pediatric medulloblastoma (MB) are at-risk for neurocognitive and social deficits, including specific skills such as facial affect recognition which is the ability to recognize the emotional expressions of another person. Because the underlying mechanisms of these deficits are poorly understood, the investigators propose to examine social-cognitive skills (i.e. facial affect recognition) and indices of brain integrity, including an established core neural network of face perception in MB survivors and healthy controls. By comparing these outcomes between survivors of MB and healthy controls, investigators seek to identify the areas of the brain that help individuals recognize emotions. Primary Objective: * To evaluate social cognition in adolescent and young adult survivors of pediatric medulloblastoma. Secondary Objective: * To examine indices of brain integrity and function and their association with facial affect recognition in survivors of pediatric medulloblastoma.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Medulloblastoma | Medulloblastoma | CURATED_BROADER | 0.80 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- Medulloblastoma Group
- description
- Medulloblastoma survivors, 30 between the ages of 12-20 years and 30 between 21-30 years.
- label
- Control Group
- description
- Health comparison group frequency matched on age (30 between the ages of 12-20 years and 30 between 21-30 years), gender and race.
Primary outcomes (1)
- measure
- Performance on standardized measures of facial affect recognition (NEPSY-II; Advanced Clinical Solutions Social Cognition)
- timeFrame
- Within two months of participant enrollment
- description
- Mean scores on measures of facial affect recognition will be compared between survivors of medulloblastoma and age, sex, and race matched community controls.
Secondary outcomes (3)
- measure
- Performance on tests of visual spatial processing and executive functioning using standardized neurocognitive assessment measures
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 12 Years
- Maximum age
- 30 Years
Show eligibility criteria text
Inclusion Criteria - Medulloblastoma Survivors: * Enrolled on the SJLIFE protocol at St. Jude Children's Research Hospital (SJCRH). * Completed treatment for medulloblastoma at SJCRH. * Infratentorial tumor location. * Treated with craniospinal irradiation. * ≥ 5 years post diagnosis. * Between 12 and 30 years of age at time of enrollment. * English speaking. Inclusion Criteria - Controls: * Enrolled on the SJLIFE protocol as a community control. * Between 12 and 30 years of age at time of enrollment. * English speaking. Exclusion Criteria - Medulloblastoma Survivors: * Diagnosis of a genetic disorder/pre-existing neurodevelopmental condition associated with neurocognitive or social impairment (e.g., down syndrome, autism). * History of head injury associated with neurocognitive impairment. * Diagnosis of a serious psychiatric condition associated with neurocognitive or social morbidities (e.g. schizophrenia). * Currently pregnant (due to MRI studies). * Implanted metal unsafe for MRI or medical device (i.e. pacemaker) * Requires sedation to complete MRI. * Legally blind or unaidable hearing loss. * Treated for medulloblastoma \<3 years of age * Received re-irradiation to the brain. * Completed SJLIFE HPP-19 (pilot study) at SJCRH. Exclusion Criteria - Controls: * No history of childhood cancer or cancer related therapy. * First degree relative or direct friend of medulloblastoma participant. * Diagnosis of a genetic disorder/neurodevelopmental condition associated with neurocognitive or social impairment (e.g., down syndrome, autism). * History of head injury associated with neurocognitive impairment. * Diagnosis of a serious psychiatric condition associated with neurocognitive or social morbidities (e.g. schizophrenia). * Currently pregnant (due to MRI studies). * Implanted metal unsafe for MRI or medical device (i.e. pacemaker). * Requires sedation to complete MRI. * Legally blind or unaidable hearing loss.
References
Publications (0)
Data not yet available