Clinical trial · Observational
Bronchial Mapping (GCC 1635)
Investigating Radiation-Induced Injury to Airways and Pulmonary Vasculature in Lung Stereotactic Ablative Body Radiotherapy (SAbR)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Grant ended, slow accrual- enrollment goal not met.
Summary
Brief summary (as posted)
In order to better understand radiation-induced lung toxicity, the investigator proposes a novel functional avoidance approach that incorporates central as well as peripheral BSS segments in the treatment planning process in order to quantify and account for their respective radiosensitivities. Specifically, the investigator proposes a systematic study that involves acquiring pre- and post-SAbR high-resolution CT and SPECT V/Q scans from lung cancer patients who receive radiotherapy, followed by auto-segmentation of the BSS elements using virtual bronchoscopy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Thoracic Cancer | Malignant Thoracic Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (2)
- measure
- Number of patients that show an association between radiation-induced collapse of branching serial structures elements and localized change in pulmonary function
- timeFrame
- 3 years
- description
- Evaluating the association of RT and how branching structures change in lung function
- measure
- Radiosensitivity of peripheral BSS segments in terms of dose dependent probability of collapse.
- timeFrame
- 3 years
- description
- Evaluating the difference between dose and segmental collapse with pre- and post treatment MRI's
Secondary outcomes (1)
- measure
- Number of patients analyzed for creation of intensity modulated radiotherapy treatment plans that incorporate radiation dose thresholds for BSS elements
- timeFrame
- 3 years
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with primary or metastatic lung lesions to be treated using stereotactic ablative radiotherapy (There is no limitation on the location or number of lesions for this study) OR Conventionally fractionated RT patients with primary or metastatic lung lesions * Age ≥ 18 years. No gender or ethnic restrictions. * Performance status ECOG ≥ 3 * Ability to hold breath for \~20 seconds * Ability to understand and the willingness to sign a written informed consent. * Any types and amounts of prior therapy will be allowed for this study. * Maximum PTV dimension ≤ 70 mm Exclusion Criteria: * Children (age \<18 years). * Women who are pregnant, nursing, or trying to get pregnant. * ECOG performance status \< 3
References
Publications (0)
Data not yet available