Clinical trial · Interventional
Efficacy of Acupuncture in Prevention of Chemotherapy Induced Peripheral Neuropathy - a Pilot Study
Randomized, Assessor- and Participant-blinded, Controlled, and Parallel-design Approach to Investigate Whether Acupuncture Can Prevent or Postpone the Occurrence of Peripheral Neuropathy and Improve Quality of Life.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of this pilot study is to investigate the efficacy of acupuncture in prevention of chemotherapy induced peripheral neuropathy. The study adapted a single center, randomized, assessor- and participant-blinded, controlled, and parallel-design approach to investigate whether acupuncture can prevent or postpone the occurrence of peripheral neuropathy and improve quality of life.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Verum acupuncture | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Verum acupuncture
- description
- 16 patients will be randomized to receive verum acupuncture two times biweekly, prior to beginning chemotherapy and the weeks that drugs administered, for 26 treatments in total.
- interventionNames
- Other: Verum acupuncture
- type
- PLACEBO_COMPARATOR
- label
- Sham acupuncture
- description
- 16 patients will be randomized to receive sham acupuncture two times biweekly, prior to beginning chemotherapy and the weeks that drugs administered, for 26 treatments in total.
- interventionNames
- Other: Verum acupuncture
Primary outcomes (2)
- measure
- Change from Baseline in NCV at 48weeks.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patients were diagnosed as stage 3 colorectal cancer. 2. Patients are going to receive Oxaliplatin based chemotherapy. 3. Patients are willing to cooperate with physicians and completely receive chemotherapy. 4. Patients are willing to receive acupuncture treatments and follow-up assessments. 5. Adult volunteers with the ages of 20-70 years old. 6. ECOG Performance Status of 0, 1, or 2 Exclusion Criteria: 1. Current active treatments with chemotherapy, radiotherapy or tumor resection surgery in the past one month. 2. Having chemotherapy with neuropathic agents including taxane, platinum, vinca alkaloid, bortezimab, or thalidomide in the past six months. 3. Local infection at or near the acupuncture site is not suitable for acupuncture after physician examination. 4. Concurrent use of other alternative medicines such as herbal agents, high dose vitamins and minerals. 5. Known coagulopathy or taking anticoagulants. 6. Platelets \< 50000/ul. 7. WBCs \< 3000/ul. 8. Active CNS disease 9. Cardiac pacemaker. 10. Psychological or behavior disorder such as Schizophrenia. 11. Currently pregnant or breastfeeding women. 12. History of diabetic neuropathy or neuropathy related to HIV. 13. Previous acupuncture treatment for any indication within 30 days of enrollment. 14. Current medications that could affect symptoms related to CIPN. 15. Grade III lymphedema or more severe situation
References
Publications (0)
Data not yet available