Androgen Deprivation Therapy or Androgen Deprivation Therapy Plus Definitive Treatment (Radiation or Surgery)

Inclusion Criteria:

1. Male patients;
2. 18 yrs and older, and 80 yrs and younger;
3. Histologically or cytologically proven prostate carcinoma;
4. Documented evidence of M1 disease by AJCC (American Joint Committee on Cancer) staging by Bone scan, CT and/or MRI; and metastatic lesions are limited to the lymph nodes or bones, at the same time the number of lesions should less than or equal to 5;
5. ECOG PS 0 or 1;
6. Treatment initiation with androgen deprivation therapy no longer than 6 months prior to randomization;
7. Life-expectancy based on comorbid conditions \>2 years;
8. No serious medical complications;
9. The primary lesion of prostate cancer has not yet received local treatment;
10. Must be a candidate for surgery and/or radiation therapy and follow-up and the treatment will not bring about serious complications to patients;
11. Ability to understand and willingness to sign informed consent.

Exclusion Criteria:

1. Had received treatment for primary lesion, including: radical prostatectomy, radical radiation therapy and so on;
2. Patients who received systemic chemotherapy before;
3. Androgen deprivation therapy time is greater than six months;
4. Visceral organ metastasis (liver, lung, brain and other organs);
5. Small cell carcinoma of the prostate;
6. Psychiatric or medical conditions which, in the opinion of the treating physician, would not allow the patient to undergo the proposed treatments safely;
7. Patients who are not willing to accept the complications caused by the treatment to primary lesion;
8. Combined with other malignant tumor history (in addition to the skin basal cell carcinoma or other tumors that have been cured more than five years);
9. Other serious diseases, for example: unstable heart disease after treatment, myocardial infarction in 6 months prior to treatment, cardiac function grade 3-4 (NYHA); high blood pressure that can not be controlled after medical treatment (greater than 150/90mmHg); serious neurological or mental disorders, including dementia and epilepsy; uncontrolled active infection; acute gastric ulcer; hypocalcemia; chronic obstructive pulmonary disease that needs hospital treatment;
10. Has participated in other clinical research before.