Clinical trial · Interventional
Effects of Propofol-dexmedetomidine on Immune Function in Patients With Cancer Larynx
Effects of Propofol-dexmedetomidine on Immune Function During Total Laryngectomy Surgery Compared With Isoflurane Anesthesia
NCT02739958CI-TRIAL-00047256completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of this prospective, randomized clinical study is to compare between propofol and isoflurane on perioperative immune cell populations and function in patients undergoing total laryngectomy surgery.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer Larynx | Laryngeal Neoplasm | PROBABILISTIC | 0.70 |
| Total Laryngectomy | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Isoflurane group | Drug | — | UNRESOLVED |
| Propofol group | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Propofol group
- description
- Patients receive only intravenous anesthetics
- interventionNames
- Drug: Propofol group
- type
- PLACEBO_COMPARATOR
- label
- Isoflurane group
- description
- Patients receive isoflurane /fentanyl anesthesia
- interventionNames
- Drug: Isoflurane group
Primary outcomes (1)
- measure
- CD3 plasma level
- timeFrame
- for 7 days after procedure
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 40 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: * American Society of Anesthesiologists physical status I- III * Scheduled for total laryngectomy. Exclusion Criteria: * Patients refusal. * Morbid obese patients (body mass index \>40 kg/m2). * Allergy to local anesthetics agents used. * Severely altered consciousness level. * Psychiatric disorders. * Severe or uncompensated cardiovascular disease. * Severe renal disease. * Severe hepatic disease. * Severe endocrinal diseases.
References
Publications (0)
Data not yet available
No reference posted for this study.