Clinical trial · Interventional
Alternative Exercise Program to Improve Skeletal Muscle Function and Fatigue in Cancer Survivors
NCT02739620CI-TRIAL-00065497completedN/AResults postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Exercise training has beneficial effects in cancer survivors to minimize some of the side effects of cancer and its treatment and improve long-term prognosis, but there are numerous hurdles for individuals diagnosed with, and being treated for, cancer to participate in exercise programs. The goal of this research study is to begin to evaluate whether exercise training via neuromuscular electrical stimulation (NMES) has beneficial effects on skeletal muscle size and function in cancer survivors.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Neuromuscular electrical stimulation | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- NMES
- description
- Neuromuscular electrical stimulation (NMES) group
- interventionNames
- Device: Neuromuscular electrical stimulation
- type
- NO_INTERVENTION
- label
- Control
- description
- Control group
Primary outcomes (3)
- measure
- Maximal Calcium-activated Tension Single Muscle Fiber Tension
- timeFrame
- Difference between values at baseline at 2 months
- description
- Tension (force per unit muscle fiber cross-sectional area) from segments of chemically-skinned single human muscle fibers will be assessed under maximal calcium-activated condition, with muscle fiber type determined post-measurement by gel electrophoresis
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 40 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: 1. stage I, II or III breast cancer 2. receiving neoadjuvant or adjuvant chemotherapy with or without radiation 3. a body mass index \<35 kg/m2. Exclusion Criteria: 1. metastatic disease, a prior history of cancer, excluding non-melanoma skin cancer, or prior receipt of chemotherapy 2. autoimmune, vascular or neuromuscular disease that could alter skeletal muscle 3. prior knee or hip replacement 4. contraindications for use of neuromuscular electrical stimulation, including an implanted cardiac defibrillator or pacemaker, lower extremity blood clot or coagulopathy 5. pregnancy
References
Publications (0)
Data not yet available
No reference posted for this study.